NIKD_STAAN
ID NIKD_STAAN Reviewed; 257 AA.
AC Q7A5Q8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Nickel import system ATP-binding protein NikD {ECO:0000250|UniProtKB:Q2FYQ7};
DE EC=7.2.2.11 {ECO:0000250|UniProtKB:Q2FYQ7};
GN Name=nikD {ECO:0000250|UniProtKB:Q2FYQ7}; Synonyms=oppD2;
GN OrderedLocusNames=SA1212;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC in nickel import. Probably responsible for energy coupling to the
CC transport system. {ECO:0000250|UniProtKB:Q2FYQ7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11;
CC Evidence={ECO:0000250|UniProtKB:Q2FYQ7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15558;
CC Evidence={ECO:0000250|UniProtKB:Q2FYQ7};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; BA000018; BAB42472.1; -; Genomic_DNA.
DR PIR; D89914; D89914.
DR RefSeq; WP_000052315.1; NC_002745.2.
DR AlphaFoldDB; Q7A5Q8; -.
DR SMR; Q7A5Q8; -.
DR EnsemblBacteria; BAB42472; BAB42472; BAB42472.
DR KEGG; sau:SA1212; -.
DR HOGENOM; CLU_000604_1_23_9; -.
DR OMA; THSFNDH; -.
DR Proteomes; UP000000751; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Ion transport; Membrane; Nickel;
KW Nickel transport; Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..257
FT /note="Nickel import system ATP-binding protein NikD"
FT /id="PRO_0000276798"
FT DOMAIN 4..245
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 257 AA; 29699 MW; 39E02ECE67351190 CRC64;
MSLIDIQNLT IKNTCEKYLI KGIDLKIFSQ QINALIGESG AGKSLIAKAL LEYLPFDLSC
TYDSYQFDGE NISRLSQYYG HTIGYISQNY AESFNDHTKL GKQLTAIYRK HYKSSKEEAL
SKIDKALSWV NLQSKDILNK YSFQLSGGQL ERVYIASVLM LEPKLIIADE PVASLDALNG
NQVMDLLQHI VLEHGQTLFI ITHNLSHVLK YCQYIYVLKE GQIIERGNIN HFKYEHLHPY
TERLIKYRTQ LKRDYYD