位置:首页 > 蛋白库 > NIKE_BRUSU
NIKE_BRUSU
ID   NIKE_BRUSU              Reviewed;         266 AA.
AC   Q8FVN0; G0KDG6; Q9AL78;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Nickel import ATP-binding protein NikE {ECO:0000255|HAMAP-Rule:MF_01712};
DE            EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01712};
GN   Name=nikE {ECO:0000255|HAMAP-Rule:MF_01712};
GN   OrderedLocusNames=BRA0800, BS1330_II0793;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=1330;
RX   PubMed=11133934; DOI=10.1128/jb.183.2.426-434.2001;
RA   Jubier-Maurin V., Rodrigue A., Ouahrani-Bettache S., Layssac M.,
RA   Mandrand-Berthelot M.-A., Koehler S., Liautard J.-P.;
RT   "Identification of the nik gene cluster of Brucella suis: regulation and
RT   contribution to urease activity.";
RL   J. Bacteriol. 183:426-434(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC       nickel import. Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01712}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC         Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC         ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01712};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01712}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01712}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01712}.
CC   -!- INDUCTION: Induced by low oxygen tension and metal ion deficiency.
CC       Repressed by NiCl(2) excess. {ECO:0000269|PubMed:11133934}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC       (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01712}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ278644; CAC24697.1; -; Genomic_DNA.
DR   EMBL; AE014292; AAN33978.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM20254.1; -; Genomic_DNA.
DR   RefSeq; WP_004687156.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FVN0; -.
DR   SMR; Q8FVN0; -.
DR   EnsemblBacteria; AEM20254; AEM20254; BS1330_II0793.
DR   GeneID; 45053815; -.
DR   KEGG; bms:BRA0800; -.
DR   KEGG; bsi:BS1330_II0793; -.
DR   PATRIC; fig|204722.21.peg.3645; -.
DR   HOGENOM; CLU_000604_1_23_5; -.
DR   OMA; LVERFCH; -.
DR   PhylomeDB; Q8FVN0; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR014137; Nickel_NikE.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02769; nickel_nikE; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51248; NIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Nickel; Nickel transport; Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..266
FT                   /note="Nickel import ATP-binding protein NikE"
FT                   /id="PRO_0000092626"
FT   DOMAIN          4..252
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01712"
FT   BINDING         45..52
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01712"
FT   CONFLICT        121
FT                   /note="S -> F (in Ref. 1; CAC24697)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   266 AA;  29148 MW;  8BC0D121A2731DFC CRC64;
     MSLISADNIV KIYQSHSLVG ASARKTVLHD ISISIGQGET VALLGRSGCG KSTLARLLVG
     LERPTSGEVR FRGVPLTKLD RSGMKAFRRE VQLIFQDSPG AVNARSSVRA IIGEPLRHLT
     SLDETRREER IQELLRLVEL PPEIADRLPA QVSGGQLQRI CIARALAVNP KLIILDEAVS
     NLDIHLQASA LALLTKLQQE GGIAYLFVTH DLRLVQKFAA RCLVMDEGQI VEEIKTADLD
     SMRHPASRLL REAVLPPLPV RAVETN
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024