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NIKR1_METTH
ID   NIKR1_METTH             Reviewed;         127 AA.
AC   O26703;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Putative nickel-responsive regulator 1;
GN   OrderedLocusNames=MTH_603;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence={ECO:0000250};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB85109.1; -; Genomic_DNA.
DR   PIR; B69180; B69180.
DR   RefSeq; WP_010876242.1; NC_000916.1.
DR   AlphaFoldDB; O26703; -.
DR   SMR; O26703; -.
DR   STRING; 187420.MTH_603; -.
DR   EnsemblBacteria; AAB85109; AAB85109; MTH_603.
DR   GeneID; 1470564; -.
DR   KEGG; mth:MTH_603; -.
DR   HOGENOM; CLU_113319_0_1_2; -.
DR   OMA; YCMELFV; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   SUPFAM; SSF55021; SSF55021; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nickel; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..127
FT                   /note="Putative nickel-responsive regulator 1"
FT                   /id="PRO_0000139308"
FT   BINDING         74
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         85
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         87
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   127 AA;  14549 MW;  7F0A4D16411B35AA CRC64;
     MVVVSVSLGE KLLEEIDALR DELGFSGRSD VIRVAARMLI DEKRNLHELN GEINAVLFLI
     HPRRVEDLVT KIKHDYEDII GTQLHSHLKD GNCLELFIIE GESMRVRELA ERFLACGKMK
     HIKLVTF
 
 
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