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NIKR_BRUME
ID   NIKR_BRUME              Reviewed;         132 AA.
AC   Q8YCP2;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Nickel-responsive regulator;
GN   Name=nikR; OrderedLocusNames=BMEII0486;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Transcriptional repressor of the nikABCDE operon. Is active
CC       in the presence of excessive concentrations of intracellular nickel (By
CC       similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence={ECO:0000250};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL53728.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008918; AAL53728.1; ALT_INIT; Genomic_DNA.
DR   PIR; AE3570; AE3570.
DR   RefSeq; WP_004682148.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YCP2; -.
DR   SMR; Q8YCP2; -.
DR   STRING; 224914.BMEII0486; -.
DR   EnsemblBacteria; AAL53728; AAL53728; BMEII0486.
DR   GeneID; 29595702; -.
DR   KEGG; bme:BMEII0486; -.
DR   PATRIC; fig|224914.52.peg.2886; -.
DR   eggNOG; COG0864; Bacteria.
DR   OMA; AHNCLET; -.
DR   PhylomeDB; Q8YCP2; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR014160; Nickel_NikR_proteobac.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   SUPFAM; SSF55021; SSF55021; 1.
DR   TIGRFAMs; TIGR02793; nikR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nickel; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..132
FT                   /note="Nickel-responsive regulator"
FT                   /id="PRO_0000139283"
FT   BINDING         77
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         90
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
FT   BINDING         96
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14960 MW;  953E68CF6B3E5A37 CRC64;
     MQRITITIDD DLMAALDRMI EIKGYQNRSE ALRDLARTGL QQASLEEGQM EACVGVLSYT
     YDHSARDLSK KLTNTHHDHH NISVASMHVH LDHDRCLEVS ILKSKTDDVR HFADHVKAER
     HVTHGTLAVL PL
 
 
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