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NIKR_DESDA
ID   NIKR_DESDA              Reviewed;         138 AA.
AC   B8J1Q4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Putative nickel-responsive regulator {ECO:0000255|HAMAP-Rule:MF_00476};
GN   OrderedLocusNames=Ddes_1765;
OS   Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=525146;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27774 / DSM 6949 / MB;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Sims D., Lu M., Kiss H., Meineke L., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Hazen T.C.;
RT   "Complete sequence of Desulfovibrio desulfuricans subsp. desulfuricans str.
RT   ATCC 27774.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000255|HAMAP-Rule:MF_00476}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00476};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00476};
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000255|HAMAP-Rule:MF_00476}.
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DR   EMBL; CP001358; ACL49662.1; -; Genomic_DNA.
DR   RefSeq; WP_012625386.1; NC_011883.1.
DR   AlphaFoldDB; B8J1Q4; -.
DR   SMR; B8J1Q4; -.
DR   STRING; 525146.Ddes_1765; -.
DR   EnsemblBacteria; ACL49662; ACL49662; Ddes_1765.
DR   KEGG; dds:Ddes_1765; -.
DR   eggNOG; COG0864; Bacteria.
DR   HOGENOM; CLU_113319_1_2_7; -.
DR   OMA; AHNCLET; -.
DR   OrthoDB; 1885366at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   SUPFAM; SSF55021; SSF55021; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nickel; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..138
FT                   /note="Putative nickel-responsive regulator"
FT                   /id="PRO_1000135550"
FT   BINDING         78
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         89
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         91
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         97
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
SQ   SEQUENCE   138 AA;  15680 MW;  F00755DB1C6985F9 CRC64;
     MGNLARFGVS LDQDLLEPFD ELCRRKSYPN RSEAIRDLIR KALVEEKWNS DAHGAGTLTL
     VYDHHKNDLS RRLVQIQHDD HDLIVTTLHV HLDHYNCLEV LVLKGEPKRM RALADKLIAC
     RGVKHGTFTG TTTGEDLA
 
 
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