ID   NIKR_METM5              Reviewed;         141 AA.
AC   A4G0H7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Putative nickel-responsive regulator {ECO:0000255|HAMAP-Rule:MF_00476};
GN   OrderedLocusNames=MmarC5_1664;
OS   Methanococcus maripaludis (strain C5 / ATCC BAA-1333).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=402880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC BAA-1333;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C.,
RA   Detter J.C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of chromosome of Methanococcus maripaludis C5.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000255|HAMAP-Rule:MF_00476}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00476};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00476};
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000255|HAMAP-Rule:MF_00476}.
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DR   EMBL; CP000609; ABO35961.1; -; Genomic_DNA.
DR   RefSeq; WP_011869408.1; NC_009135.1.
DR   AlphaFoldDB; A4G0H7; -.
DR   SMR; A4G0H7; -.
DR   STRING; 402880.MmarC5_1664; -.
DR   EnsemblBacteria; ABO35961; ABO35961; MmarC5_1664.
DR   GeneID; 4929310; -.
DR   KEGG; mmq:MmarC5_1664; -.
DR   eggNOG; arCOG01008; Archaea.
DR   HOGENOM; CLU_113319_1_2_2; -.
DR   OMA; AHNCLET; -.
DR   OrthoDB; 90041at2157; -.
DR   Proteomes; UP000000253; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 1.
DR   Gene3D; 3.30.70.1150; -; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   SUPFAM; SSF55021; SSF55021; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nickel; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..141
FT                   /note="Putative nickel-responsive regulator"
FT                   /id="PRO_1000014073"
FT   BINDING         80
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         91
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         93
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
FT   BINDING         99
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00476"
SQ   SEQUENCE   141 AA;  16075 MW;  9D39080C7B94D576 CRC64;
     MVDMDRISIS LPTNLLAEFD EIIEERGYAS RSEAIRDSIR DYLIKHKWIH SLEGDRAGTI
     SIIYDHHSTD VMEKLTNIQH DYEKLIVATI HMHLDHDHCM EVVLVKGDAS EIKELTDKLT
     SQKGVKQVKL TVMVPGGNIP Q