NILR1_RAT
ID NILR1_RAT Reviewed; 547 AA.
AC D3ZQX2; A2J8C0;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 3.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Neutrophil immunoglobulin-like receptor 1 {ECO:0000303|PubMed:10382763};
DE Flags: Precursor;
GN Name=Nilr1 {ECO:0000303|PubMed:10382763};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|Proteomes:UP000002494};
RN [1] {ECO:0000312|EMBL:AAD29110.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=PVG {ECO:0000312|EMBL:AAD29110.1};
RC TISSUE=Natural killer cell {ECO:0000303|PubMed:10382763};
RX PubMed=10382763;
RX DOI=10.1002/(sici)1521-4141(199906)29:06<2000::aid-immu2000>3.0.co;2-5;
RA Berg S.F., Fossum S., Dissen E.;
RT "NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic
RT granulocytes, is encoded by a leukocyte receptor gene complex on rat
RT chromosome 1.";
RL Eur. J. Immunol. 29:2000-2006(1999).
RN [2] {ECO:0000312|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000312|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3] {ECO:0000312|EMBL:EDL84917.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expression detected in neutrophilic granulocytes.
CC {ECO:0000269|PubMed:10382763}.
CC -!- DOMAIN: Contains 4 copies of a cytoplasmic motif that is referred to as
CC the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is
CC involved in modulation of cellular responses. The phosphorylated ITIM
CC motif can bind the SH2 domain of several SH2-containing phosphatases.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDL84917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF082534; AAD29110.1; -; mRNA.
DR EMBL; AABR07071875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH474101; EDL84917.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_113901.2; NM_031713.1.
DR AlphaFoldDB; D3ZQX2; -.
DR SMR; D3ZQX2; -.
DR STRING; 10116.ENSRNOP00000015054; -.
DR GlyGen; D3ZQX2; 2 sites.
DR PaxDb; D3ZQX2; -.
DR Ensembl; ENSRNOT00000084439; ENSRNOP00000075718; ENSRNOG00000054954.
DR GeneID; 65146; -.
DR KEGG; rno:65146; -.
DR UCSC; RGD:70895; rat.
DR CTD; 10288; -.
DR RGD; 70895; Nilr1.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR GeneTree; ENSGT01000000214458; -.
DR HOGENOM; CLU_021100_2_3_1; -.
DR InParanoid; D3ZQX2; -.
DR OrthoDB; 1000446at2759; -.
DR PhylomeDB; D3ZQX2; -.
DR TreeFam; TF336644; -.
DR PRO; PR:D3ZQX2; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Proteomes; UP000234681; Chromosome 1.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; ISO:RGD.
DR GO; GO:0050839; F:cell adhesion molecule binding; ISO:RGD.
DR GO; GO:0032396; F:inhibitory MHC class I receptor activity; ISO:RGD.
DR GO; GO:0042288; F:MHC class I protein binding; ISO:RGD.
DR GO; GO:0023029; F:MHC class Ib protein binding; ISO:RGD.
DR GO; GO:0023025; F:MHC class Ib protein complex binding; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0008157; F:protein phosphatase 1 binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISO:RGD.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; ISO:RGD.
DR GO; GO:0002767; P:immune response-inhibiting cell surface receptor signaling pathway; ISO:RGD.
DR GO; GO:0140105; P:interleukin-10-mediated signaling pathway; ISO:RGD.
DR GO; GO:0002578; P:negative regulation of antigen processing and presentation; ISO:RGD.
DR GO; GO:0051926; P:negative regulation of calcium ion transport; ISO:RGD.
DR GO; GO:2000524; P:negative regulation of T cell costimulation; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0002666; P:positive regulation of T cell tolerance induction; ISO:RGD.
DR GO; GO:0002645; P:positive regulation of tolerance induction; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..547
FT /note="Neutrophil immunoglobulin-like receptor 1"
FT /id="PRO_0000435369"
FT TOPO_DOM 24..345
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..547
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 34..119
FT /note="Ig-like C2-type 1"
FT /evidence="ECO:0000255"
FT DOMAIN 132..222
FT /note="Ig-like C2-type 2"
FT /evidence="ECO:0000255"
FT DOMAIN 233..321
FT /note="Ig-like C2-type 3"
FT /evidence="ECO:0000255"
FT REGION 377..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 417..422
FT /note="ITIM motif 1"
FT /evidence="ECO:0000303|PubMed:10382763"
FT MOTIF 446..451
FT /note="ITIM motif 2"
FT /evidence="ECO:0000303|PubMed:10382763"
FT MOTIF 498..503
FT /note="ITIM motif 3"
FT /evidence="ECO:0000303|PubMed:10382763"
FT MOTIF 528..533
FT /note="ITIM motif 4"
FT /evidence="ECO:0000303|PubMed:10382763"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..99
FT /evidence="ECO:0000305"
FT DISULFID 147..199
FT /evidence="ECO:0000305"
FT DISULFID 248..299
FT /evidence="ECO:0000305"
SQ SEQUENCE 547 AA; 61258 MW; 44EBCAC3304D9A0C CRC64;
MTFTCKALLC LGMTLGLWIT VLTEFLPRPI LRVQPDTVVS TQSKVIFFCE RSQGAELYCL
YKKGNPRNPR CKEIRPKPGK KVEFFISKIE PYHAGHYHCY YQIHGQWSED SDALELVVTG
VYDYNELRLS VLPSPVVTVG RNMTLHCISH SHYDKFILTK EDHKFTSSLD TQCIPPSGQC
QALFVMGPMT SNHTGTFRCY GYYKHTPQLW SIPSEPLEIH ISGLSKKPSL LTHQGHILDP
GVNLTLQCCS DINYDRFALY KVGGVDIMQH TSQQTDTGFS MTNFTLGYVH HSTGGQYRCY
GAHNLSSEWS ASSDPLDILI TGPIQMSTLP PITSMPPDQL ESYVNALIGV SVAFLVFLFI
LIFIILQRRH QRKFRKDGEE AQKEKELQYP TGAVEPISRD RDQQKRSNAA AATQEESVYA
SVEDMETEDG VELDTWKPPE GDPQGETYAQ VKPSRLRRVE AIIPSAMSRE QLNTKYEQAE
EGQEVDGQAT ESEEPQDVTY AQLCSRTLRQ GTAAPPLSQA GEAPEEPSVY AALATACPGA
VPKDKEQ
