NIMR_ECOLI
ID NIMR_ECOLI Reviewed; 273 AA.
AC P76241; Q2MB28;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=HTH-type transcriptional regulator NimR {ECO:0000305};
DE AltName: Full=Regulator of nimT {ECO:0000303|PubMed:25790494};
GN Name=nimR {ECO:0000303|PubMed:25790494}; Synonyms=yeaM;
GN OrderedLocusNames=b1790, JW1779;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP FUNCTION, AND INDUCTION.
RC STRAIN=K12;
RX PubMed=25790494; DOI=10.1093/femsle/fnu013;
RA Ogasawara H., Ohe S., Ishihama A.;
RT "Role of transcription factor NimR (YeaM) in sensitivity control of
RT Escherichia coli to 2-nitroimidazole.";
RL FEMS Microbiol. Lett. 362:1-8(2015).
CC -!- FUNCTION: Negatively regulates expression of the nimT operon and its
CC own expression. Acts by binding to the nimR-nimT intergenic region.
CC {ECO:0000269|PubMed:25790494}.
CC -!- INDUCTION: Negatively autoregulated. {ECO:0000269|PubMed:25790494}.
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DR EMBL; U00096; AAC74860.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76528.1; -; Genomic_DNA.
DR PIR; F64939; F64939.
DR RefSeq; NP_416304.1; NC_000913.3.
DR RefSeq; WP_000972248.1; NZ_SSZK01000001.1.
DR AlphaFoldDB; P76241; -.
DR SMR; P76241; -.
DR BioGRID; 4260327; 11.
DR IntAct; P76241; 15.
DR STRING; 511145.b1790; -.
DR PaxDb; P76241; -.
DR PRIDE; P76241; -.
DR EnsemblBacteria; AAC74860; AAC74860; b1790.
DR EnsemblBacteria; BAE76528; BAE76528; BAE76528.
DR GeneID; 946590; -.
DR KEGG; ecj:JW1779; -.
DR KEGG; eco:b1790; -.
DR PATRIC; fig|511145.12.peg.1864; -.
DR EchoBASE; EB3272; -.
DR eggNOG; COG2207; Bacteria.
DR HOGENOM; CLU_000445_87_0_6; -.
DR InParanoid; P76241; -.
DR OMA; AHRHDDH; -.
DR PhylomeDB; P76241; -.
DR BioCyc; EcoCyc:G6976-MON; -.
DR PRO; PR:P76241; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR003313; AraC-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF02311; AraC_binding; 1.
DR Pfam; PF12833; HTH_18; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..273
FT /note="HTH-type transcriptional regulator NimR"
FT /id="PRO_0000194611"
FT DOMAIN 158..258
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 178..199
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT DNA_BIND 225..248
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ SEQUENCE 273 AA; 30554 MW; 51A7E8E6D5827980 CRC64;
MMHRLNLNGY EPDRHHEAAV AFCIHAGTDE LTSPVHQHRK GQLILALHGA ITCTVENALW
MVPPQYAVWI PGGVEHSNQV TANAELCFLF IEPSAVTMPT TCCTLKISPL CRELILTLAN
RTTTQRAEPM TRRLIQVLFD ELPQQPQQQL HLPVSSHPKI RTMVEMMAKG PVEWGALGQW
AGFFAMSERN LARLIVKETG LSFRQWRQQL QLIMALQGLV KGDTVQKVAH TLGYDSTTAF
ITMFKKGLGQ TPGRYIARLT TVSPQSAKPD PRQ
