NINJ2_HUMAN
ID NINJ2_HUMAN Reviewed; 142 AA.
AC Q9NZG7;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Ninjurin-2;
DE AltName: Full=Nerve injury-induced protein 2;
GN Name=NINJ2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10627596; DOI=10.1523/jneurosci.20-01-00187.2000;
RA Araki T., Milbrandt J.;
RT "Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature
RT sensory and enteric neurons and promotes neurite outgrowth.";
RL J. Neurosci. 20:187-195(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Homophilic cell adhesion molecule that promotes axonal
CC growth. May play a role in nerve regeneration and in the formation and
CC function of other tissues.
CC -!- INTERACTION:
CC Q9NZG7; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-10317425, EBI-19125216;
CC Q9NZG7; Q13520: AQP6; NbExp=3; IntAct=EBI-10317425, EBI-13059134;
CC Q9NZG7; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10317425, EBI-11343438;
CC Q9NZG7; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-10317425, EBI-747430;
CC Q9NZG7; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-10317425, EBI-17953245;
CC Q9NZG7; Q07108: CD69; NbExp=4; IntAct=EBI-10317425, EBI-2836595;
CC Q9NZG7; P11912: CD79A; NbExp=3; IntAct=EBI-10317425, EBI-7797864;
CC Q9NZG7; P40198: CEACAM3; NbExp=3; IntAct=EBI-10317425, EBI-12851752;
CC Q9NZG7; Q9H9P2: CHODL; NbExp=3; IntAct=EBI-10317425, EBI-17447707;
CC Q9NZG7; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-10317425, EBI-11977093;
CC Q9NZG7; Q9BXN2: CLEC7A; NbExp=3; IntAct=EBI-10317425, EBI-3939278;
CC Q9NZG7; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10317425, EBI-18013275;
CC Q9NZG7; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-10317425, EBI-6942903;
CC Q9NZG7; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-10317425, EBI-2680384;
CC Q9NZG7; Q15125: EBP; NbExp=3; IntAct=EBI-10317425, EBI-3915253;
CC Q9NZG7; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10317425, EBI-18535450;
CC Q9NZG7; Q9NYP7: ELOVL5; NbExp=3; IntAct=EBI-10317425, EBI-11037623;
CC Q9NZG7; O14944: EREG; NbExp=3; IntAct=EBI-10317425, EBI-17272224;
CC Q9NZG7; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10317425, EBI-781551;
CC Q9NZG7; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-10317425, EBI-17973325;
CC Q9NZG7; P34910-2: EVI2B; NbExp=3; IntAct=EBI-10317425, EBI-17640610;
CC Q9NZG7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10317425, EBI-18304435;
CC Q9NZG7; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-10317425, EBI-18938272;
CC Q9NZG7; P55899: FCGRT; NbExp=3; IntAct=EBI-10317425, EBI-2833934;
CC Q9NZG7; Q96PJ5: FCRL4; NbExp=3; IntAct=EBI-10317425, EBI-4314687;
CC Q9NZG7; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-10317425, EBI-12142257;
CC Q9NZG7; P17302: GJA1; NbExp=3; IntAct=EBI-10317425, EBI-1103439;
CC Q9NZG7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10317425, EBI-13345167;
CC Q9NZG7; O15529: GPR42; NbExp=3; IntAct=EBI-10317425, EBI-18076404;
CC Q9NZG7; P32942: ICAM3; NbExp=3; IntAct=EBI-10317425, EBI-725421;
CC Q9NZG7; P15260: IFNGR1; NbExp=3; IntAct=EBI-10317425, EBI-1030755;
CC Q9NZG7; P26951: IL3RA; NbExp=3; IntAct=EBI-10317425, EBI-1757512;
CC Q9NZG7; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10317425, EBI-10266796;
CC Q9NZG7; P48051: KCNJ6; NbExp=3; IntAct=EBI-10317425, EBI-12017638;
CC Q9NZG7; P43628: KIR2DL3; NbExp=3; IntAct=EBI-10317425, EBI-8632435;
CC Q9NZG7; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-10317425, EBI-17272405;
CC Q9NZG7; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-10317425, EBI-10173166;
CC Q9NZG7; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-10317425, EBI-2820517;
CC Q9NZG7; Q6UWN5: LYPD5; NbExp=3; IntAct=EBI-10317425, EBI-17200970;
CC Q9NZG7; Q9Y5Y7: LYVE1; NbExp=3; IntAct=EBI-10317425, EBI-10329546;
CC Q9NZG7; P20645: M6PR; NbExp=3; IntAct=EBI-10317425, EBI-2907262;
CC Q9NZG7; O14880: MGST3; NbExp=3; IntAct=EBI-10317425, EBI-724754;
CC Q9NZG7; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-10317425, EBI-6163737;
CC Q9NZG7; Q95460-2: MR1; NbExp=3; IntAct=EBI-10317425, EBI-12201447;
CC Q9NZG7; P15941-11: MUC1; NbExp=3; IntAct=EBI-10317425, EBI-17263240;
CC Q9NZG7; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-10317425, EBI-12382569;
CC Q9NZG7; P57054: PIGP; NbExp=3; IntAct=EBI-10317425, EBI-17630288;
CC Q9NZG7; P15151: PVR; NbExp=3; IntAct=EBI-10317425, EBI-3919694;
CC Q9NZG7; Q7Z5B4-5: RIC3; NbExp=3; IntAct=EBI-10317425, EBI-12375429;
CC Q9NZG7; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-10317425, EBI-18397230;
CC Q9NZG7; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-10317425, EBI-17247926;
CC Q9NZG7; Q9P0V8: SLAMF8; NbExp=3; IntAct=EBI-10317425, EBI-18164173;
CC Q9NZG7; Q14973: SLC10A1; NbExp=3; IntAct=EBI-10317425, EBI-3923031;
CC Q9NZG7; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10317425, EBI-18159983;
CC Q9NZG7; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-10317425, EBI-12889586;
CC Q9NZG7; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-10317425, EBI-5235586;
CC Q9NZG7; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-10317425, EBI-13292283;
CC Q9NZG7; Q16623: STX1A; NbExp=3; IntAct=EBI-10317425, EBI-712466;
CC Q9NZG7; P32856-2: STX2; NbExp=3; IntAct=EBI-10317425, EBI-11956649;
CC Q9NZG7; Q53R12: TM4SF20; NbExp=3; IntAct=EBI-10317425, EBI-1805798;
CC Q9NZG7; Q96IK0: TMEM101; NbExp=3; IntAct=EBI-10317425, EBI-3922699;
CC Q9NZG7; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-10317425, EBI-7238458;
CC Q9NZG7; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10317425, EBI-8638294;
CC Q9NZG7; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-10317425, EBI-726044;
CC Q9NZG7; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10317425, EBI-18178701;
CC Q9NZG7; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-10317425, EBI-2548832;
CC Q9NZG7; Q9P0T7: TMEM9; NbExp=3; IntAct=EBI-10317425, EBI-723976;
CC Q9NZG7; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10317425, EBI-12345267;
CC Q9NZG7; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10317425, EBI-6447886;
CC Q9NZG7; O95859: TSPAN12; NbExp=3; IntAct=EBI-10317425, EBI-2466403;
CC Q9NZG7; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-10317425, EBI-1055364;
CC Q9NZG7; Q86XK7: VSIG1; NbExp=3; IntAct=EBI-10317425, EBI-18323486;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed. In adult, higher expression in
CC the bone marrow and peripheral blood lymphocytes, medium in the lung,
CC lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal
CC muscle, lower in the liver, placenta, brain, heart and kidney. In
CC embryo, higher expression in the thymus, heart and liver, lower in the
CC spleen, lung, brain and kidney.
CC -!- INDUCTION: By nerve injury; in Schwann cells.
CC -!- SIMILARITY: Belongs to the ninjurin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57766.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF205633; AAF42828.1; -; mRNA.
DR EMBL; BC057766; AAH57766.2; ALT_INIT; mRNA.
DR CCDS; CCDS8505.1; -.
DR RefSeq; NP_001281274.1; NM_001294345.1.
DR RefSeq; NP_001281275.1; NM_001294346.1.
DR RefSeq; NP_057617.2; NM_016533.5.
DR AlphaFoldDB; Q9NZG7; -.
DR BioGRID; 110880; 75.
DR IntAct; Q9NZG7; 72.
DR STRING; 9606.ENSP00000307552; -.
DR iPTMnet; Q9NZG7; -.
DR PhosphoSitePlus; Q9NZG7; -.
DR BioMuta; NINJ2; -.
DR DMDM; 18203328; -.
DR jPOST; Q9NZG7; -.
DR MassIVE; Q9NZG7; -.
DR PaxDb; Q9NZG7; -.
DR PeptideAtlas; Q9NZG7; -.
DR PRIDE; Q9NZG7; -.
DR ProteomicsDB; 83384; -.
DR Antibodypedia; 22080; 94 antibodies from 17 providers.
DR DNASU; 4815; -.
DR Ensembl; ENST00000305108.10; ENSP00000307552.5; ENSG00000171840.13.
DR GeneID; 4815; -.
DR KEGG; hsa:4815; -.
DR MANE-Select; ENST00000305108.10; ENSP00000307552.5; NM_016533.6; NP_057617.3.
DR UCSC; uc001qil.4; human.
DR CTD; 4815; -.
DR DisGeNET; 4815; -.
DR GeneCards; NINJ2; -.
DR HGNC; HGNC:7825; NINJ2.
DR HPA; ENSG00000171840; Tissue enhanced (brain).
DR MIM; 607297; gene.
DR neXtProt; NX_Q9NZG7; -.
DR OpenTargets; ENSG00000171840; -.
DR PharmGKB; PA31632; -.
DR VEuPathDB; HostDB:ENSG00000171840; -.
DR eggNOG; ENOG502S2EJ; Eukaryota.
DR GeneTree; ENSGT00940000158219; -.
DR HOGENOM; CLU_093971_1_0_1; -.
DR InParanoid; Q9NZG7; -.
DR OrthoDB; 1560683at2759; -.
DR PhylomeDB; Q9NZG7; -.
DR TreeFam; TF323538; -.
DR PathwayCommons; Q9NZG7; -.
DR SignaLink; Q9NZG7; -.
DR BioGRID-ORCS; 4815; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; NINJ2; human.
DR GenomeRNAi; 4815; -.
DR Pharos; Q9NZG7; Tbio.
DR PRO; PR:Q9NZG7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NZG7; protein.
DR Bgee; ENSG00000171840; Expressed in blood and 140 other tissues.
DR ExpressionAtlas; Q9NZG7; baseline and differential.
DR Genevisible; Q9NZG7; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0007158; P:neuron cell-cell adhesion; TAS:ProtInc.
DR GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR InterPro; IPR007007; Ninjurin.
DR PANTHER; PTHR12316; PTHR12316; 1.
DR Pfam; PF04923; Ninjurin; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..142
FT /note="Ninjurin-2"
FT /id="PRO_0000159646"
FT TOPO_DOM 1..65
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 142 AA; 15680 MW; B00A92F5EAFF6BD9 CRC64;
MESARENIDL QPGSSDPRSQ PINLNHYATK KSVAESMLDV ALFMSNAMRL KAVLEQGPSS
HYYTTLVTLI SLSLLLQVVI GVLLVVIARL NLNEVEKQWR LNQLNNAATI LVFFTVVINV
FITAFGAHKT GFLAARASRN PL
