NINJ2_MOUSE
ID NINJ2_MOUSE Reviewed; 143 AA.
AC Q9JL89;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ninjurin-2;
DE AltName: Full=Nerve injury-induced protein 2;
GN Name=Ninj2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10627596; DOI=10.1523/jneurosci.20-01-00187.2000;
RA Araki T., Milbrandt J.;
RT "Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature
RT sensory and enteric neurons and promotes neurite outgrowth.";
RL J. Neurosci. 20:187-195(2000).
CC -!- FUNCTION: Homophilic cell adhesion molecule that promotes axonal
CC growth. May play a role in nerve regeneration and in the formation and
CC function of other tissues.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: In the dorsal root ganglia, already detected at
CC embryonic day 14, increasing until postnatal day 2 where the adult
CC level is reached.
CC -!- INDUCTION: By nerve injury; in Schwann cells.
CC -!- SIMILARITY: Belongs to the ninjurin family. {ECO:0000305}.
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DR EMBL; AF205634; AAF42829.1; -; mRNA.
DR CCDS; CCDS39612.1; -.
DR RefSeq; NP_057927.1; NM_016718.2.
DR AlphaFoldDB; Q9JL89; -.
DR STRING; 10090.ENSMUSP00000108331; -.
DR PhosphoSitePlus; Q9JL89; -.
DR PaxDb; Q9JL89; -.
DR PRIDE; Q9JL89; -.
DR Antibodypedia; 22080; 94 antibodies from 17 providers.
DR DNASU; 29862; -.
DR Ensembl; ENSMUST00000112711; ENSMUSP00000108331; ENSMUSG00000041377.
DR GeneID; 29862; -.
DR KEGG; mmu:29862; -.
DR UCSC; uc009dmx.1; mouse.
DR CTD; 4815; -.
DR MGI; MGI:1352751; Ninj2.
DR VEuPathDB; HostDB:ENSMUSG00000041377; -.
DR eggNOG; ENOG502S2EJ; Eukaryota.
DR GeneTree; ENSGT00940000158219; -.
DR HOGENOM; CLU_093971_1_0_1; -.
DR InParanoid; Q9JL89; -.
DR OMA; SQYYTTL; -.
DR OrthoDB; 1560683at2759; -.
DR PhylomeDB; Q9JL89; -.
DR TreeFam; TF323538; -.
DR BioGRID-ORCS; 29862; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ninj2; mouse.
DR PRO; PR:Q9JL89; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9JL89; protein.
DR Bgee; ENSMUSG00000041377; Expressed in primary oocyte and 30 other tissues.
DR ExpressionAtlas; Q9JL89; baseline and differential.
DR Genevisible; Q9JL89; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR InterPro; IPR007007; Ninjurin.
DR PANTHER; PTHR12316; PTHR12316; 1.
DR Pfam; PF04923; Ninjurin; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..143
FT /note="Ninjurin-2"
FT /id="PRO_0000159647"
FT TOPO_DOM 1..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 143 AA; 15994 MW; A822707AF10132BF CRC64;
MESDRETIHL QHRHSMRGGN QRIDLNFYAT KKSVAESMLD VALFMSNAMR LKSVLQQGPF
AEYYTTLVTL IIVSLLLQVV ISLLLVFIAI LNLNEVENQR HLNKLNNAAT ILVFITVVIN
IFITAFGAHH AASMAARTSS NPI
