ID   NINJ2_RAT               Reviewed;         144 AA.
AC   Q9JHE8;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Ninjurin-2;
DE   AltName: Full=Nerve injury-induced protein 2;
GN   Name=Ninj2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Li W., Tian Q.B., Okano A., Suzuki T.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Homophilic cell adhesion molecule that promotes axonal
CC       growth. May play a role in nerve regeneration and in the formation and
CC       function of other tissues.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By nerve injury; in Schwann cells.
CC   -!- SIMILARITY: Belongs to the ninjurin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB040815; BAA94291.1; -; mRNA.
DR   EMBL; AF250322; AAF65567.1; -; mRNA.
DR   RefSeq; NP_067606.1; NM_021595.2.
DR   AlphaFoldDB; Q9JHE8; -.
DR   SMR; Q9JHE8; -.
DR   STRING; 10116.ENSRNOP00000013721; -.
DR   PaxDb; Q9JHE8; -.
DR   Ensembl; ENSRNOT00000097409; ENSRNOP00000083990; ENSRNOG00000010282.
DR   GeneID; 59115; -.
DR   KEGG; rno:59115; -.
DR   UCSC; RGD:620552; rat.
DR   CTD; 4815; -.
DR   RGD; 620552; Ninj2.
DR   eggNOG; ENOG502S2EJ; Eukaryota.
DR   GeneTree; ENSGT00940000158219; -.
DR   HOGENOM; CLU_093971_1_0_1; -.
DR   InParanoid; Q9JHE8; -.
DR   OMA; SQYYTTL; -.
DR   OrthoDB; 1560683at2759; -.
DR   PhylomeDB; Q9JHE8; -.
DR   TreeFam; TF323538; -.
DR   PRO; PR:Q9JHE8; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000010282; Expressed in cerebellum and 12 other tissues.
DR   Genevisible; Q9JHE8; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR   InterPro; IPR007007; Ninjurin.
DR   PANTHER; PTHR12316; PTHR12316; 1.
DR   Pfam; PF04923; Ninjurin; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..144
FT                   /note="Ninjurin-2"
FT                   /id="PRO_0000159648"
FT   TOPO_DOM        1..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..108
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..144
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   144 AA;  15996 MW;  EED7A2ACA61A838D CRC64;
     MESDREIIHL QHRHSTPGGN QRHINLNHYA TKKSVAESML DVALFMSNAM RLKSVLEQGP
     FSQYYTTLLT LISASLLLQV VIGILLVVIA RLNLNEVENQ WRLNQLNNAA TTLVFITVVI
     NIFITAFGAH KTGSVAARTS SNPI