NIP31_ARATH
ID NIP31_ARATH Reviewed; 323 AA.
AC Q9C6T0;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Aquaporin NIP3-1;
DE AltName: Full=NOD26-like intrinsic protein 3-1;
DE Short=AtNIP3;1;
GN Name=NIP3-1; OrderedLocusNames=At1g31885; ORFNames=F5M6.28;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NOMENCLATURE.
RX PubMed=11806824; DOI=10.1186/gb-2001-3-1-research0001;
RA Quigley F., Rosenberg J.M., Shachar-Hill Y., Bohnert H.J.;
RT "From genome to function: the Arabidopsis aquaporins.";
RL Genome Biol. 3:RESEARCH0001.1-RESEARCH0001.17(2002).
CC -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC neutral solutes across cell membranes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC membrane-spanning domains and a pore-forming loop with the signature
CC motif Asn-Pro-Ala (NPA).
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC
CC 1.A.8.12) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50717.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079041; AAG50717.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31413.1; -; Genomic_DNA.
DR PIR; B86443; B86443.
DR RefSeq; NP_001323362.1; NM_001332986.1.
DR RefSeq; NP_174472.2; NM_102926.3.
DR AlphaFoldDB; Q9C6T0; -.
DR SMR; Q9C6T0; -.
DR STRING; 3702.AT1G31885.1; -.
DR PaxDb; Q9C6T0; -.
DR EnsemblPlants; AT1G31885.1; AT1G31885.1; AT1G31885.
DR GeneID; 840079; -.
DR Gramene; AT1G31885.1; AT1G31885.1; AT1G31885.
DR KEGG; ath:AT1G31885; -.
DR Araport; AT1G31885; -.
DR TAIR; locus:2826185; AT1G31885.
DR eggNOG; KOG0223; Eukaryota.
DR HOGENOM; CLU_020019_3_1_1; -.
DR InParanoid; Q9C6T0; -.
DR OMA; HNIFFEC; -.
DR OrthoDB; 1152704at2759; -.
DR PhylomeDB; Q9C6T0; -.
DR PRO; PR:Q9C6T0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6T0; baseline and differential.
DR Genevisible; Q9C6T0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR PANTHER; PTHR45724; PTHR45724; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
DR TIGRFAMs; TIGR00861; MIP; 1.
DR PROSITE; PS00221; MIP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..323
FT /note="Aquaporin NIP3-1"
FT /id="PRO_0000064065"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT MOTIF 102..104
FT /note="NPA 1"
FT MOTIF 221..223
FT /note="NPA 2"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P61837"
SQ SEQUENCE 323 AA; 34579 MW; 348B51FFFF10748D CRC64;
MAEISDITTQ TQTVVLDIEN YQSIDDSRSS DLSAPLVSVS FVQKLIGEFV GTFTMIFAGC
SAIVVNETYG KPVTLPGIAL VWGLVVTVMI YSIGHVSGAH FNPAVSIAFA SSKKFPFNQV
PGYIAAQLLG STLAAAVLRL VFHLDDDVCS LKGDVYVGTY PSNSNTTSFV MEFIATFNLM
FVISAVATDK RATGSFAGIA IGATIVLDIL FSGPISGASM NPARSLGPAL IWGCYKDLWL
YIVSPVIGAL SGAWTYGLLR STKKSYSEII RPNCNKVSSR DRQEASQDEI CVLRVVDPAN
QNYFICSSPT DINGKCNVTC KLA
