ID   NIP31_MAIZE             Reviewed;         302 AA.
AC   Q9ATN1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Aquaporin NIP3-1;
DE   AltName: Full=NOD26-like intrinsic protein 3-1;
DE   AltName: Full=ZmNIP3-1;
DE   AltName: Full=ZmNIP3;1;
GN   Name=NIP3-1; Synonyms=NIP3A;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. B73;
RX   PubMed=11244102; DOI=10.1104/pp.125.3.1206;
RA   Chaumont F., Barrieu F., Wojcik E., Chrispeels M.J., Jung R.;
RT   "Aquaporins constitute a large and highly divergent protein family in
RT   maize.";
RL   Plant Physiol. 125:1206-1215(2001).
CC   -!- FUNCTION: Aquaporins facilitate the transport of water and small
CC       neutral solutes across cell membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala (NPA).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC
CC       1.A.8.12) subfamily. {ECO:0000305}.
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DR   EMBL; AF326486; AAK26753.1; -; mRNA.
DR   RefSeq; NP_001105021.1; NM_001111551.1.
DR   AlphaFoldDB; Q9ATN1; -.
DR   SMR; Q9ATN1; -.
DR   STRING; 4577.GRMZM2G176209_P01; -.
DR   PaxDb; Q9ATN1; -.
DR   EnsemblPlants; Zm00001eb043650_T001; Zm00001eb043650_P001; Zm00001eb043650.
DR   GeneID; 541885; -.
DR   Gramene; Zm00001eb043650_T001; Zm00001eb043650_P001; Zm00001eb043650.
DR   KEGG; zma:541885; -.
DR   MaizeGDB; 403452; -.
DR   eggNOG; KOG0223; Eukaryota.
DR   HOGENOM; CLU_020019_3_1_1; -.
DR   OMA; ASQSNCW; -.
DR   OrthoDB; 1152704at2759; -.
DR   Proteomes; UP000007305; Chromosome 1.
DR   ExpressionAtlas; Q9ATN1; baseline and differential.
DR   Genevisible; Q9ATN1; ZM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:EnsemblPlants.
DR   GO; GO:0046715; F:active borate transmembrane transporter activity; IEA:EnsemblPlants.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:EnsemblPlants.
DR   GO; GO:0015250; F:water channel activity; IEA:EnsemblPlants.
DR   GO; GO:0080029; P:cellular response to boron-containing substance levels; IEA:EnsemblPlants.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:EnsemblPlants.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR45724; PTHR45724; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..302
FT                   /note="Aquaporin NIP3-1"
FT                   /id="PRO_0000286034"
FT   TRANSMEM        76..96
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           133..135
FT                   /note="NPA 1"
FT                   /evidence="ECO:0000250"
FT   MOTIF           246..248
FT                   /note="NPA 2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   302 AA;  31162 MW;  70A81F2311FE56A4 CRC64;
     MEPGSTPPNG SAPATPGTPA PLFSSGGPRV DSLSYERKSM PRCKCLPLPA VEGWGVATHT
     CVVEIPAPDV SLTRKLGAEF VGTFILIFFA TAAPIVNQKY GGAISPFGNA ACAGLAVATV
     ILSTGHISGA HLNPSLTIAF AALRHFPWLQ VPAYVAVQAL ASVCAAFALK GVFHPFLSGG
     VTVPDATVST AQAFFTEFII SFNLLFVVTA VATDTRAVGE LAGIAVGAAV TLNILVAGPT
     TGGSMNPVRT LGPAVAAGNY RQLWIYLLAP TLGALAGASV YKAVKLRDEN GETPRTQRSF
     RR