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NIP51_ARATH
ID   NIP51_ARATH             Reviewed;         304 AA.
AC   Q9SV84;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Probable aquaporin NIP5-1;
DE   AltName: Full=NOD26-like intrinsic protein 5-1;
DE            Short=AtNIP5;1;
DE   AltName: Full=Nodulin-26-like major intrinsic protein 6;
DE            Short=NodLikeMip6;
DE            Short=Protein NLM6;
GN   Name=NIP5-1; Synonyms=NLM6; OrderedLocusNames=At4g10380;
GN   ORFNames=F24G24.180;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NOMENCLATURE, AND TISSUE SPECIFICITY.
RX   PubMed=11806824; DOI=10.1186/gb-2001-3-1-research0001;
RA   Quigley F., Rosenberg J.M., Shachar-Hill Y., Bohnert H.J.;
RT   "From genome to function: the Arabidopsis aquaporins.";
RL   Genome Biol. 3:RESEARCH0001.1-RESEARCH0001.17(2002).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=16679457; DOI=10.1105/tpc.106.041640;
RA   Takano J., Wada M., Ludewig U., Schaaf G., von Wiren N., Fujiwara T.;
RT   "The Arabidopsis major intrinsic protein NIP5;1 is essential for efficient
RT   boron uptake and plant development under boron limitation.";
RL   Plant Cell 18:1498-1509(2006).
CC   -!- FUNCTION: Boric acid transporter. Low water transport activity. Plays
CC       an important role as plasma membrane boric acid channel for the boron
CC       uptake required for plant growth and development under boron
CC       limitation. {ECO:0000269|PubMed:16679457}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16679457};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:16679457}.
CC   -!- TISSUE SPECIFICITY: Expressed in rosette leaves.
CC       {ECO:0000269|PubMed:11806824}.
CC   -!- INDUCTION: By boron limitation in the root elongation and the root hair
CC       zones. {ECO:0000269|PubMed:16679457}.
CC   -!- DOMAIN: Aquaporins contain two tandem repeats each containing three
CC       membrane-spanning domains and a pore-forming loop with the signature
CC       motif Asn-Pro-Ala/Ser/Val (NPA).
CC   -!- DISRUPTION PHENOTYPE: Plants display lower boric acid uptake into
CC       roots, lower biomass production, and increased sensitivity of root and
CC       shoot development to boron deficiency. {ECO:0000269|PubMed:16679457}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC
CC       1.A.8.12) subfamily. {ECO:0000305}.
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DR   EMBL; AL049488; CAB39791.1; -; Genomic_DNA.
DR   EMBL; AL161517; CAB78161.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82874.1; -; Genomic_DNA.
DR   EMBL; AY087560; AAM65102.1; -; mRNA.
DR   PIR; T04053; T04053.
DR   RefSeq; NP_192776.1; NM_117106.3.
DR   AlphaFoldDB; Q9SV84; -.
DR   SMR; Q9SV84; -.
DR   STRING; 3702.AT4G10380.1; -.
DR   TCDB; 1.A.8.12.3; the major intrinsic protein (mip) family.
DR   PaxDb; Q9SV84; -.
DR   PRIDE; Q9SV84; -.
DR   ProteomicsDB; 249443; -.
DR   EnsemblPlants; AT4G10380.1; AT4G10380.1; AT4G10380.
DR   GeneID; 826630; -.
DR   Gramene; AT4G10380.1; AT4G10380.1; AT4G10380.
DR   KEGG; ath:AT4G10380; -.
DR   Araport; AT4G10380; -.
DR   TAIR; locus:2122829; AT4G10380.
DR   eggNOG; KOG0223; Eukaryota.
DR   HOGENOM; CLU_020019_3_1_1; -.
DR   InParanoid; Q9SV84; -.
DR   OMA; ASQSNCW; -.
DR   OrthoDB; 1152704at2759; -.
DR   PhylomeDB; Q9SV84; -.
DR   PRO; PR:Q9SV84; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q9SV84; baseline and differential.
DR   Genevisible; Q9SV84; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016328; C:lateral plasma membrane; IDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0046715; F:active borate transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0015250; F:water channel activity; IDA:TAIR.
DR   GO; GO:0015700; P:arsenite transport; IDA:TAIR.
DR   GO; GO:0046713; P:borate transport; IDA:TAIR.
DR   GO; GO:0080029; P:cellular response to boron-containing substance levels; IEP:TAIR.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IMP:TAIR.
DR   GO; GO:0010036; P:response to boron-containing substance; IMP:TAIR.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR45724; PTHR45724; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; SSF81338; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..304
FT                   /note="Probable aquaporin NIP5-1"
FT                   /id="PRO_0000064068"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   MOTIF           137..139
FT                   /note="NPA 1"
FT   MOTIF           248..250
FT                   /note="NPA 2"
FT   MOD_RES         301
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P43286"
SQ   SEQUENCE   304 AA;  31493 MW;  0B7D0C626F723337 CRC64;
     MAPPEAEVGA VMVMAPPTPG TPGTPGGPLI TGMRVDSMSF DHRKPTPRCK CLPVMGSTWG
     QHDTCFTDFP SPDVSLTRKL GAEFVGTFIL IFTATAGPIV NQKYDGAETL IGNAACAGLA
     VMIIILSTGH ISGAHLNPSL TIAFAALRHF PWAHVPAYIA AQVSASICAS FALKGVFHPF
     MSGGVTIPSV SLGQAFALEF IITFILLFVV TAVATDTRAV GELAGIAVGA TVMLNILVAG
     PSTGGSMNPV RTLGPAVASG NYRSLWVYLV APTLGAISGA AVYTGVKLND SVTDPPRPVR
     SFRR
 
 
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