ID   NIP7_DANRE              Reviewed;         180 AA.
AC   Q503P2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog;
GN   Name=nip7; ORFNames=zgc:110384;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome
CC       subunit assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with pre-ribosome complex. May bind to RNA.
CC       Interacts with NOL8. Interacts with FTSJ3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000305}.
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DR   EMBL; BC095238; AAH95238.1; -; mRNA.
DR   RefSeq; NP_001018426.1; NM_001020590.1.
DR   AlphaFoldDB; Q503P2; -.
DR   SMR; Q503P2; -.
DR   STRING; 7955.ENSDARP00000076524; -.
DR   PaxDb; Q503P2; -.
DR   Ensembl; ENSDART00000082087; ENSDARP00000076524; ENSDARG00000059075.
DR   GeneID; 553616; -.
DR   KEGG; dre:553616; -.
DR   CTD; 51388; -.
DR   ZFIN; ZDB-GENE-050522-256; nip7.
DR   eggNOG; KOG3492; Eukaryota.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_097217_0_0_1; -.
DR   InParanoid; Q503P2; -.
DR   OMA; YKIWVKP; -.
DR   OrthoDB; 1405073at2759; -.
DR   PhylomeDB; Q503P2; -.
DR   TreeFam; TF300081; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q503P2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000059075; Expressed in presomitic mesoderm and 38 other tissues.
DR   ExpressionAtlas; Q503P2; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR   Gene3D; 2.30.130.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR   InterPro; IPR040598; UPF0113_N.
DR   InterPro; IPR005155; UPF0113_PUA.
DR   Pfam; PF03657; UPF0113; 1.
DR   Pfam; PF17833; UPF0113_N; 1.
DR   PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..180
FT                   /note="60S ribosome subunit biogenesis protein NIP7
FT                   homolog"
FT                   /id="PRO_0000355567"
FT   DOMAIN          94..170
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
FT   REGION          1..92
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250"
FT   REGION          93..180
FT                   /note="C-terminal domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20609 MW;  885308B3401BBCEC CRC64;
     MRPLTDEETK TMFEKLSKYI GENIKLLIDR PDGTYCFRLH NDRVYYMSEK ILKLATNVSR
     DKLVSVGTCF GKFTKTQKFR LHITALDFLA PYAKFKVWVK PGSEQSFLYG NHIMKSGLGR
     ITENTDKYQG VLVYSMADVP LGFGVAARTT QECRKVDPMA IVVFHQADIG EYIRSEDTLT