NIP7_DICDI
ID NIP7_DICDI Reviewed; 179 AA.
AC B0G104; Q86JG8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog;
GN Name=nip7; ORFNames=DDB_G0295477;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for proper 27S pre-rRNA processing and 60S ribosome
CC subunit assembly. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Interacts with pre-ribosome complex. May bind to RNA
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000305}.
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DR EMBL; AAFI02000006; EDR41108.1; -; Genomic_DNA.
DR RefSeq; XP_001732966.1; XM_001732914.1.
DR AlphaFoldDB; B0G104; -.
DR SMR; B0G104; -.
DR STRING; 44689.DDB0235213; -.
DR PaxDb; B0G104; -.
DR EnsemblProtists; EDR41108; EDR41108; DDB_G0295477.
DR GeneID; 8618043; -.
DR KEGG; ddi:DDB_G0295477; -.
DR dictyBase; DDB_G0295477; nip7.
DR eggNOG; KOG3492; Eukaryota.
DR HOGENOM; CLU_097217_0_0_1; -.
DR InParanoid; B0G104; -.
DR OMA; YKIWVKP; -.
DR PhylomeDB; B0G104; -.
DR PRO; PR:B0G104; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:dictyBase.
DR GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR Gene3D; 2.30.130.10; -; 1.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR InterPro; IPR040598; UPF0113_N.
DR InterPro; IPR005155; UPF0113_PUA.
DR Pfam; PF03657; UPF0113; 1.
DR Pfam; PF17833; UPF0113_N; 1.
DR PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT CHAIN 1..179
FT /note="60S ribosome subunit biogenesis protein NIP7
FT homolog"
FT /id="PRO_0000328001"
FT DOMAIN 94..170
FT /note="PUA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ SEQUENCE 179 AA; 20699 MW; ADBB1BC17CA35985 CRC64;
MRPMTEEESK TFFEKLIKFI GKNVTLLIQR KDEPYCFRIQ KNKVYYVSEE LMKRSQNIPR
EGLCSLGTCF GRFTKTGKFK LNITCLDYLA QYAKYKVWVK PSSEMSWMYG NNLLKAGLGR
ITEDTPANQG VVLFSMNDVP IGFGVTSKST HECRKLDPQA LVVYHYGDVG EYLRDEDIM