ID   NIP7_PIG                Reviewed;         180 AA.
AC   Q56P27; Q52QS1;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog;
DE   AltName: Full=Nucleolar pre-rRNA processing protein NIP7;
GN   Name=NIP7;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17187224; DOI=10.1007/s11033-006-9035-5;
RA   Liu G.Y., Xiong Y.Z.;
RT   "Isolation, sequence analysis and expression profile of a novel porcine
RT   gene, NIP7, differentially expressed in the Longissimus dorsi muscle
RT   tissues from Meishan, Meishan x Large White cross and Large White pigs.";
RL   Mol. Biol. Rep. 34:213-219(2007).
CC   -!- FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome
CC       subunit assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with pre-ribosome complex. May bind to RNA.
CC       Interacts with NOL8. Interacts with FTSJ3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in muscle, heart, liver, fat, kidney and
CC       lung. Weakly expressed in small intestine, ovary and spleen.
CC       {ECO:0000269|PubMed:17187224}.
CC   -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000305}.
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DR   EMBL; AY864609; AAX77005.1; -; mRNA.
DR   EMBL; AY974338; AAX85685.1; -; Genomic_DNA.
DR   RefSeq; NP_001041536.1; NM_001048071.1.
DR   AlphaFoldDB; Q56P27; -.
DR   SMR; Q56P27; -.
DR   STRING; 9823.ENSSSCP00000002978; -.
DR   PaxDb; Q56P27; -.
DR   PRIDE; Q56P27; -.
DR   Ensembl; ENSSSCT00000076241; ENSSSCP00000061779; ENSSSCG00000033741.
DR   Ensembl; ENSSSCT00005025291; ENSSSCP00005015307; ENSSSCG00005016078.
DR   Ensembl; ENSSSCT00025069003; ENSSSCP00025029718; ENSSSCG00025050504.
DR   Ensembl; ENSSSCT00030087047; ENSSSCP00030040174; ENSSSCG00030062234.
DR   Ensembl; ENSSSCT00035076402; ENSSSCP00035031216; ENSSSCG00035057120.
DR   Ensembl; ENSSSCT00040021479; ENSSSCP00040008976; ENSSSCG00040015962.
DR   Ensembl; ENSSSCT00045047518; ENSSSCP00045032991; ENSSSCG00045027853.
DR   Ensembl; ENSSSCT00050012074; ENSSSCP00050005062; ENSSSCG00050008921.
DR   Ensembl; ENSSSCT00055008016; ENSSSCP00055006344; ENSSSCG00055004069.
DR   Ensembl; ENSSSCT00060018900; ENSSSCP00060007622; ENSSSCG00060014292.
DR   Ensembl; ENSSSCT00065069157; ENSSSCP00065030119; ENSSSCG00065050489.
DR   Ensembl; ENSSSCT00070000975; ENSSSCP00070000852; ENSSSCG00070000519.
DR   GeneID; 595107; -.
DR   KEGG; ssc:595107; -.
DR   CTD; 51388; -.
DR   VGNC; VGNC:90747; NIP7.
DR   eggNOG; KOG3492; Eukaryota.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_097217_0_0_1; -.
DR   InParanoid; Q56P27; -.
DR   OMA; YKIWVKP; -.
DR   OrthoDB; 1405073at2759; -.
DR   TreeFam; TF300081; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Proteomes; UP000314985; Chromosome 6.
DR   Bgee; ENSSSCG00000033741; Expressed in hindlimb bud and 44 other tissues.
DR   ExpressionAtlas; Q56P27; baseline and differential.
DR   Genevisible; Q56P27; SS.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR   Gene3D; 2.30.130.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR   InterPro; IPR040598; UPF0113_N.
DR   InterPro; IPR005155; UPF0113_PUA.
DR   Pfam; PF03657; UPF0113; 1.
DR   Pfam; PF17833; UPF0113_N; 1.
DR   PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..180
FT                   /note="60S ribosome subunit biogenesis protein NIP7
FT                   homolog"
FT                   /id="PRO_0000250210"
FT   DOMAIN          94..170
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
FT   REGION          1..92
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250"
FT   REGION          93..180
FT                   /note="C-terminal domain"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        33
FT                   /note="G -> D (in Ref. 1; AAX85685)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   180 AA;  20491 MW;  3F8A4A11E391DDD2 CRC64;
     MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEK ILKLAANISG
     DKLMSLGTCF GKFTKTHKFR LHITALDYLA PYAKYKVWIK PGAEQSFLYG NHVLKSGLGR
     ITENTSQYQG VVVYSMADIP LGFGVAAKST QDCRKVDPMA IVVFHQADIG EYVRHEETLT