ID   NIP7_RAT                Reviewed;         180 AA.
AC   Q9WV50; Q5RJL7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog;
DE   AltName: Full=Nucleolar pre-rRNA processing protein NIP7;
DE   AltName: Full=PEachy;
DE   AltName: Full=kDa93;
GN   Name=Nip7; Synonyms=Peachy;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RA   Wang Z., Tenniswood M.;
RT   "Cloning and characterization of pEachy, a rat sequence with homology to
RT   Saccharomyces cerevisiae Nip7p.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary, and Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome
CC       subunit assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with pre-ribosome complex. May bind to RNA.
CC       Interacts with NOL8. Interacts with FTSJ3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000305}.
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DR   EMBL; AF158186; AAD42887.1; -; mRNA.
DR   EMBL; BC059114; AAH59114.1; -; mRNA.
DR   EMBL; BC086589; AAH86589.1; -; mRNA.
DR   RefSeq; NP_620202.1; NM_138847.1.
DR   AlphaFoldDB; Q9WV50; -.
DR   SMR; Q9WV50; -.
DR   STRING; 10116.ENSRNOP00000027653; -.
DR   PhosphoSitePlus; Q9WV50; -.
DR   PaxDb; Q9WV50; -.
DR   Ensembl; ENSRNOT00000027653; ENSRNOP00000027653; ENSRNOG00000020391.
DR   GeneID; 192180; -.
DR   KEGG; rno:192180; -.
DR   UCSC; RGD:620069; rat.
DR   CTD; 51388; -.
DR   RGD; 620069; Nip7.
DR   eggNOG; KOG3492; Eukaryota.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_097217_0_0_1; -.
DR   InParanoid; Q9WV50; -.
DR   OMA; YKIWVKP; -.
DR   OrthoDB; 1405073at2759; -.
DR   PhylomeDB; Q9WV50; -.
DR   TreeFam; TF300081; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q9WV50; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000020391; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q9WV50; RN.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR   Gene3D; 2.30.130.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR   InterPro; IPR040598; UPF0113_N.
DR   InterPro; IPR005155; UPF0113_PUA.
DR   Pfam; PF03657; UPF0113; 1.
DR   Pfam; PF17833; UPF0113_N; 1.
DR   PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..180
FT                   /note="60S ribosome subunit biogenesis protein NIP7
FT                   homolog"
FT                   /id="PRO_0000218775"
FT   DOMAIN          94..170
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
FT   REGION          1..92
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250"
FT   REGION          93..180
FT                   /note="C-terminal domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20432 MW;  B39D7B9ED8E5509A CRC64;
     MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEM ILKLAANISG
     DKLVSLGTCF GKFTKTHKFR LHVTALDFLA PYAKYKVWIK PGAEQSFLYG NHVLKSGLGR
     ITENTSQYQG VVVYSMADVP LGFGVAAKST QDCRKVDPMA IVVFHQADIG EYIRHEETLT