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NIP7_TETNG
ID   NIP7_TETNG              Reviewed;         180 AA.
AC   Q4T2X8;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog;
GN   Name=nip7; ORFNames=GSTENG00008117001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome
CC       subunit assembly. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Interacts with pre-ribosome complex. May bind to RNA.
CC       Interacts with NOL8. Interacts with FTSJ3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000305}.
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DR   EMBL; CAAE01010152; CAF92754.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4T2X8; -.
DR   SMR; Q4T2X8; -.
DR   STRING; 99883.ENSTNIP00000007313; -.
DR   Ensembl; ENSTNIT00000007471; ENSTNIP00000007313; ENSTNIG00000004660.
DR   KEGG; tng:GSTEN00008117G001; -.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_097217_0_0_1; -.
DR   InParanoid; Q4T2X8; -.
DR   OMA; YKIWVKP; -.
DR   TreeFam; TF300081; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR   Gene3D; 2.30.130.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR   InterPro; IPR040598; UPF0113_N.
DR   InterPro; IPR005155; UPF0113_PUA.
DR   Pfam; PF03657; UPF0113; 1.
DR   Pfam; PF17833; UPF0113_N; 1.
DR   PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..180
FT                   /note="60S ribosome subunit biogenesis protein NIP7
FT                   homolog"
FT                   /id="PRO_0000355568"
FT   DOMAIN          94..170
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
FT   REGION          1..92
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250"
FT   REGION          93..180
FT                   /note="C-terminal domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20486 MW;  21D1703511DEFC11 CRC64;
     MRPLTEEETK TMFEKLSKYI GENIKLLVDR PDGTYCFRLH NDRVYYMSER ILKLATNIAR
     QKLVSVGTCF GKFTKTSKFR LHITALDFLA PYAKFKVWVK PGAEQSFLYG NHVLKSGLGR
     ITENTAQYQG VVVYSMADVP LGFGVAAKST QECRRVDPMS IVVFHQADVG EFIRNEDSLT
 
 
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