ID   NIPA2_PONAB             Reviewed;         360 AA.
AC   Q5R7Q3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Magnesium transporter NIPA2;
DE   AltName: Full=Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog;
GN   Name=NIPA2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a selective Mg(2+) transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Early endosome {ECO:0000250}. Note=Recruited to
CC       the cell membrane in response to low extracellular magnesium.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NIPA family. {ECO:0000305}.
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DR   EMBL; CR860059; CAH92207.1; -; mRNA.
DR   RefSeq; NP_001126291.1; NM_001132819.1.
DR   RefSeq; XP_009247865.1; XM_009249590.1.
DR   RefSeq; XP_009247866.1; XM_009249591.1.
DR   RefSeq; XP_009247867.1; XM_009249592.1.
DR   RefSeq; XP_009247868.1; XM_009249593.1.
DR   RefSeq; XP_009247869.1; XM_009249594.1.
DR   RefSeq; XP_009247870.1; XM_009249595.1.
DR   RefSeq; XP_009247871.1; XM_009249596.1.
DR   AlphaFoldDB; Q5R7Q3; -.
DR   STRING; 9601.ENSPPYP00000007097; -.
DR   Ensembl; ENSPPYT00000046057; ENSPPYP00000040152; ENSPPYG00000006259.
DR   GeneID; 100173267; -.
DR   KEGG; pon:100173267; -.
DR   CTD; 81614; -.
DR   eggNOG; KOG2922; Eukaryota.
DR   GeneTree; ENSGT00940000155651; -.
DR   HOGENOM; CLU_012349_1_1_1; -.
DR   InParanoid; Q5R7Q3; -.
DR   OMA; IWWAGMI; -.
DR   OrthoDB; 754939at2759; -.
DR   TreeFam; TF313214; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR008521; Mg_trans_NIPA.
DR   PANTHER; PTHR12570; PTHR12570; 1.
DR   Pfam; PF05653; Mg_trans_NIPA; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endosome; Ion transport; Magnesium; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..360
FT                   /note="Magnesium transporter NIPA2"
FT                   /id="PRO_0000191745"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..107
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..215
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..278
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   360 AA;  39185 MW;  A8ED640DA7AF7F4B CRC64;
     MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG HAYLKEWLWW
     AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS SYFLNERLNL HGKIGCLLSI
     LGSTVMVIHA PKEEEIETLN EMSHKLGDPG FVVFATLVVI VALILIFVVG PRHGQTNILV
     YITICSVIGA FSVSCVKGLG IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL
     DIFNTSIVTP IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
     DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV SRRNGNLTAF