NIPA6_ARATH
ID NIPA6_ARATH Reviewed; 328 AA.
AC Q8GWX2; Q9SKQ1;
DT 01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable magnesium transporter NIPA6;
GN OrderedLocusNames=At2g21120; ORFNames=F26H11.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a Mg(2+) transporter. Can also transport other
CC divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but
CC to a much less extent than Mg(2+) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited to
CC the cell membrane in response to low extracellular magnesium.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NIPA (TC 2.A.7) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD29804.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006264; AAD29804.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07125.1; -; Genomic_DNA.
DR EMBL; AK118581; BAC43181.1; -; mRNA.
DR EMBL; BT026119; ABG48475.1; -; mRNA.
DR PIR; D84597; D84597.
DR RefSeq; NP_179708.2; NM_127682.4.
DR AlphaFoldDB; Q8GWX2; -.
DR STRING; 3702.AT2G21120.1; -.
DR iPTMnet; Q8GWX2; -.
DR PaxDb; Q8GWX2; -.
DR PRIDE; Q8GWX2; -.
DR ProteomicsDB; 250534; -.
DR EnsemblPlants; AT2G21120.1; AT2G21120.1; AT2G21120.
DR GeneID; 816647; -.
DR Gramene; AT2G21120.1; AT2G21120.1; AT2G21120.
DR KEGG; ath:AT2G21120; -.
DR Araport; AT2G21120; -.
DR TAIR; locus:2047112; AT2G21120.
DR eggNOG; KOG2922; Eukaryota.
DR HOGENOM; CLU_012349_1_1_1; -.
DR InParanoid; Q8GWX2; -.
DR OMA; NVALRRY; -.
DR OrthoDB; 754939at2759; -.
DR PhylomeDB; Q8GWX2; -.
DR PRO; PR:Q8GWX2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GWX2; baseline and differential.
DR Genevisible; Q8GWX2; AT.
DR GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0043621; F:protein self-association; IPI:TAIR.
DR GO; GO:0051607; P:defense response to virus; IGI:TAIR.
DR GO; GO:0015693; P:magnesium ion transport; ISS:UniProtKB.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570; PTHR12570; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; Ion transport; Magnesium; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..328
FT /note="Probable magnesium transporter NIPA6"
FT /id="PRO_0000430294"
FT TOPO_DOM 1..4
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 35580 MW; EBDF986F88E3BDB3 CRC64;
METDNGKGLI LAVASSVFIG SSFILKKKGL KRAGAIGTRA GYGGYTYLLE PLWWAGMVTM
IVGEAANFVA YIYAPAVLVT PLGALSIIIS AVLAHFLLKE KLKKMGVLGC VSCIVGSVVI
VIHAPKEQTP NSVEEIWNLA TQPAFLIYVA ITMSIVLALI LHFEPLCGQT NILVYIGICS
LMGALTVMSI KAIGIAIKLT MEGVSQIGYP QTWLFVMVAV TCVVTQLIYL NKALDTFNAA
IVSPVYYVMF TTLTIVASAI MFKDWSGQDA ASVASELCGF ITVLTGTMIL HGTREEEQQQ
ASSEHVRWYD SRKSMNEEHL VSLYSPEY
