NIPL1_ARATH
ID NIPL1_ARATH Reviewed; 221 AA.
AC Q9FKX5;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=NEP1-interacting protein-like 1;
DE AltName: Full=RING-H2 finger protein ATL27;
GN Name=ATL27; OrderedLocusNames=At5g66070; ORFNames=K2A18.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY ORGANIZATION.
RX PubMed=11983057; DOI=10.1186/gb-2002-3-4-research0016;
RA Kosarev P., Mayer K.F.X., Hardtke C.S.;
RT "Evaluation and classification of RING-finger domains encoded by the
RT Arabidopsis genome.";
RL Genome Biol. 3:RESEARCH0016.1-RESEARCH0016.12(2002).
RN [5]
RP NOMENCLATURE, AND GENE FAMILY ORGANIZATION.
RX PubMed=16557337; DOI=10.1007/s00239-005-0038-y;
RA Serrano M., Parra S., Alcaraz L.D., Guzman P.;
RT "The ATL gene family from Arabidopsis thaliana and Oryza sativa comprises a
RT large number of putative ubiquitin ligases of the RING-H2 type.";
RL J. Mol. Evol. 62:434-445(2006).
RN [6]
RP INDUCTION BY CHITIN.
RX PubMed=17722694; DOI=10.1094/mpmi-20-8-0900;
RA Libault M., Wan J., Czechowski T., Udvardi M., Stacey G.;
RT "Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-
RT ligase genes responding to chitin, a plant-defense elicitor.";
RL Mol. Plant Microbe Interact. 20:900-911(2007).
CC -!- FUNCTION: May be involved in the early steps of the plant defense
CC signaling pathway.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9FKX5-1; Sequence=Displayed;
CC -!- INDUCTION: Up-regulated by chitin. {ECO:0000269|PubMed:17722694}.
CC -!- SIMILARITY: Belongs to the RING-type zinc finger family. NIP subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally assigned as a member of the E3 ubiquitin-
CC protein ligase ATL subfamily. {ECO:0000305|PubMed:16557337}.
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DR EMBL; AB011474; BAB10412.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98155.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70890.1; -; Genomic_DNA.
DR EMBL; BT012531; AAS99675.1; -; mRNA.
DR EMBL; BT014957; AAT47808.1; -; mRNA.
DR RefSeq; NP_001332466.1; NM_001345743.1. [Q9FKX5-1]
DR RefSeq; NP_201408.1; NM_126005.4. [Q9FKX5-1]
DR AlphaFoldDB; Q9FKX5; -.
DR SMR; Q9FKX5; -.
DR STRING; 3702.AT5G66070.2; -.
DR EnsemblPlants; AT5G66070.1; AT5G66070.1; AT5G66070. [Q9FKX5-1]
DR EnsemblPlants; AT5G66070.5; AT5G66070.5; AT5G66070. [Q9FKX5-1]
DR GeneID; 836739; -.
DR Gramene; AT5G66070.1; AT5G66070.1; AT5G66070. [Q9FKX5-1]
DR Gramene; AT5G66070.5; AT5G66070.5; AT5G66070. [Q9FKX5-1]
DR KEGG; ath:AT5G66070; -.
DR Araport; AT5G66070; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_013137_2_1_1; -.
DR InParanoid; Q9FKX5; -.
DR PhylomeDB; Q9FKX5; -.
DR PRO; PR:Q9FKX5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKX5; baseline and differential.
DR Genevisible; Q9FKX5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR027367; Gly-zipper_YMGG.
DR InterPro; IPR044523; NIP1/2-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46151; PTHR46151; 1.
DR Pfam; PF13441; Gly-zipper_YMGG; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Metal-binding; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..221
FT /note="NEP1-interacting protein-like 1"
FT /id="PRO_0000055818"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 176..218
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 221 AA; 24115 MW; F920D32A9566676A CRC64;
MDGYYSLSPI SVLHRIKDSF HFAVSALLAN LFSALFTFFF ALVGTLLGAL TGALIGQETE
SGFIRGAAVG AISGAVFSIE VFESSLLLWQ SDESGIGCLL YLIDVIASLL SGRLVRERIG
PAMLSAVQSQ MGAVESQFQD HTDIFDTAIS KGLTGDSLNR IPKVRITDTS PEIVSCSVCL
QDFQVGETVR SLPHCHHMFH LPCIDKWLRR HASCPLCRRH L
