ID   NIPLA_DANRE             Reviewed;        2381 AA.
AC   F5HSE3; A2BGN2; F1QYK3;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Nipped-B-like protein A;
GN   Name=nipbla;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=22039349; DOI=10.1371/journal.pbio.1001181;
RA   Muto A., Calof A.L., Lander A.D., Schilling T.F.;
RT   "Multifactorial origins of heart and gut defects in nipbl-deficient
RT   zebrafish, a model of Cornelia de Lange Syndrome.";
RL   PLoS Biol. 9:E1001181-E1001181(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May play a structural role in chromatin. Involved in sister
CC       chromatid cohesion, possibly by facilitating the cohesin complex
CC       loading. Transcription factor, which may promote cortical neuron
CC       migration during brain development by regulating the transcription of
CC       crucial genes in this process (By similarity).
CC       {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22039349}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6KCD5}.
CC   -!- DEVELOPMENTAL STAGE: Detected in the early blastula, 2.5 hours post
CC       fertilization (hpf), before the onset of zygotic gene expression, and
CC       expression progressively increases, reaching a peak at late gastrula
CC       stages (9 hpf), before decreasing by 26 hpf. Maternal transcripts are
CC       detected throughout the blastoderm. Ubiquitous expression continues
CC       until early somitogenesis (12 hpf), after which transcript levels
CC       gradually decrease in the trunk (15-18 hpf), with strong expression
CC       becoming restricted to the head by 25 hpf.
CC       {ECO:0000269|PubMed:22039349}.
CC   -!- DOMAIN: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is
CC       required for interaction with chromoshadow domains. This motif requires
CC       additional residues -7, -6, +4 and +5 of the central Val which contact
CC       the chromoshadow domain (By similarity).
CC       {ECO:0000250|UniProtKB:Q6KC79}.
CC   -!- SIMILARITY: Belongs to the SCC2/Nipped-B family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM14097.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB630366; BAK23968.1; -; mRNA.
DR   EMBL; BX510907; CAM14097.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001233213.1; NM_001246284.1.
DR   AlphaFoldDB; F5HSE3; -.
DR   SMR; F5HSE3; -.
DR   STRING; 7955.ENSDARP00000117955; -.
DR   PaxDb; F5HSE3; -.
DR   PeptideAtlas; F5HSE3; -.
DR   PRIDE; F5HSE3; -.
DR   GeneID; 570900; -.
DR   KEGG; dre:570900; -.
DR   CTD; 570900; -.
DR   ZFIN; ZDB-GENE-060526-121; nipbla.
DR   eggNOG; KOG1020; Eukaryota.
DR   InParanoid; F5HSE3; -.
DR   PRO; PR:F5HSE3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0090694; C:Scc2-Scc4 cohesin loading complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0071921; P:cohesin loading; ISS:UniProtKB.
DR   GO; GO:0048565; P:digestive tract development; IGI:ZFIN.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IGI:ZFIN.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IGI:ZFIN.
DR   GO; GO:0034087; P:establishment of mitotic sister chromatid cohesion; IBA:GO_Central.
DR   GO; GO:0071169; P:establishment of protein localization to chromatin; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0003146; P:heart jogging; IMP:ZFIN.
DR   GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR   GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR026003; Cohesin_HEAT.
DR   InterPro; IPR024986; Nipped-B_C.
DR   InterPro; IPR033031; Scc2/Nipped-B.
DR   PANTHER; PTHR21704; PTHR21704; 1.
DR   Pfam; PF12765; Cohesin_HEAT; 1.
DR   Pfam; PF12830; Nipped-B_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cell cycle; Developmental protein; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..2381
FT                   /note="Nipped-B-like protein A"
FT                   /id="PRO_0000419686"
FT   REPEAT          85..124
FT                   /note="HEAT 1"
FT   REPEAT          1299..1337
FT                   /note="HEAT 2"
FT   REPEAT          1375..1413
FT                   /note="HEAT 3"
FT   REPEAT          1477..1516
FT                   /note="HEAT 4"
FT   REPEAT          1843..1881
FT                   /note="HEAT 5"
FT   REGION          131..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2005..2095
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2228..2271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           552..565
FT                   /note="PxVxL motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q6KC79"
FT   COMPBIAS        131..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..693
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2006..2022
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2068..2086
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2253..2269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2381 AA;  268124 MW;  9C949F271A823F5C CRC64;
     MNGDMPHVPI TTLAGIAGLT DLLNQLPLPS PLPGTTTKSL LYNGRVAEDV GHLLGCRDET
     LVSQLANSLS QVSTEHIELK DSLGSDELEG DVPVLLQLLM SRNPNIFRNK TAPNTPQYPA
     QAGISQQSMA PPYKITHGSM QGSPASANYQ QASMSHSPSG HFVPGQSGPG GRFLPQQGSP
     VPSPYAPQSP ATGYRQYPHP PAYSQHQHLQ QGSVASPMIP GAMRNVHENK DQMRMGFTSH
     LLQSSPPYTP PCDGTKDLHL GSQDKQRGQK SSEGEQDSPD KATVYDIVGS PAKDHTKLIL
     RPSRARPAEV ELGGMYPGSD PEGELVEALA AIERMESEAA METERSAKEV QDKDKPLKKR
     KQDSHPQEPG AAGTAGSGSG APGGGGGANA GHRLAPQEAS AAGTSASRPG LQVSLEQAGR
     VEDDCMGMPI PASEAQRWPQ EPQEGVTPKA VKHEHDHDPE HPHYDDKQPD TPRQKHRPEG
     RHGDGGAQRA AVQSGSKQVE LPPYMLGENT GVLKNFTIPK IRKGELGGGD IPEGWKQPCV
     RLERLEADVD VKKSVKPVVV LQKLSIDEVQ RLMRERDSRA SKSGKNRLSS GRSGKGGIDP
     SVLKDLPPEL LAEIESTMPL CERVKMNKRK RSTVNERPKY AEDSSEDEEF SSRKRQRKDR
     DRTWEAEERD RRSSGEHRRG NFDARRGSGS RYDDSDQDSP PPSLNEVARR LKMKQKKRKV
     YEPKLTPEEM MDSSTFKRFT LSIDNILENL EDVDFTAQDD DEIPQELLLG KQQLNELGSE
     SAKIKAMGIT SRIPSDKLVK LLNILEKNIL DGASLSTLMN LDNEGEDEER LWRDLIMERV
     TKSADACLTA LNIMTSTHMP KAVYIEDVIE RVLQYTKFHL QNTLYPQYDP VYRVNPKGGS
     MLSSRAKRAK CSTAKQKVII MLYNKVCDVV SNISELLEIQ LMTDTTILQV SSMGITPFFV
     ENVSELQLCA IKLVTAVFSR YEKHRQLILE EIFTSLARLP TSKRSLRNFR LNSSDDEGEP
     IYIQMVSALV LQLIQCVVHL PADRDSEDDH KKVDDDVFIT NSYETARRTA QNFLSVFLKK
     CGSKQGEEDY RPLFENFVQD LLSTVNKPDW PASELLLSLL GRLLVHQFSN KQTEMALRVA
     SLDYLGTVAA RLRKDSVTSR MDQKAIERII RENTEGDETQ RLQKALLDYM DENAETDPAL
     AFARKFYIAQ WFRDCTTETE KAMRSQNQKE DDSDGAQHAK ELQATGDIMQ RAETRKKFLH
     SVVKSTPNQF TTLRMNSDTV DYDDACLIVR YLASTRPFSQ SFDIYLTQIL RVLGESAIAV
     RTKAMKCLSE VVAVDPSILA RSDMQRGVHG RLMDNSTSVR EAAVELLGRF VLSRPQLTEQ
     YYDMLIERIL DTGISVRKRV IKILRDICLE QPNFSKITEM CVKMIRRVND EEGIKKLVNE
     TFQKLWFTPT PNHDKETMNR KILNITDVVS ACKDTGYDWF EQLLQNLLKS EEDSSYKPTR
     KACVQLVDNL VEHILKYEEA LAEHKSVNST RLVACITTLY LFSKIRAQLM VKHAMTMQPY
     LTTKCSSQSD FMVICNVAKI LELVVPLMDH PSESFLTTIE EDLMKLILKY GMTVVQYCVS
     CLGAIVNKVT HNYKFVWACF NRYYGALTKL KVQHQEGTNS MALAATKAAL LRSLFTAGAL
     CRHFDFDLEQ FKGTTKVVIK EKVLELLLYF TNHEDEEVKC KAIIGLGFLF IMHPSQMFVP
     EVKTLYNGLL SDKRSSITLK IQVLKNLQMY LQEEDTRMQE ADREWQKLSK QEDLKEMGDI
     SSGMSSSIMQ LYLKQVLESF FHAQSSVRHF ALNVIALTLS QGLIHPVQCV PYLIAMGTDA
     EPTMRNKADQ QLVEIDKKYT GFIHMKAVAG MKMSYQVQQA VFGSAGSVIR GFRQDESNSA
     QCSHLYSMVR ANRQHRRAFL ISLLNLFDDS SKMEVNMLLF IADNLAYFPY QSQEEPLFIM
     HHIDITLSVS GSNLLQTFKE SLVKIPGRKS RKRRRRRRRP QRQQPPPPPP QQQQQQNGSE
     EERGAQDEER ERHSGDEEYD DDDYEEDEDG HRVRKPKPTE DIRQSESDSD SDLDDVDAVM
     ERLPDDSTSL VDFARASQGI LLLLVLKQHL KNLYGFSDGK IQKYSPSESA KVYDKAVNRK
     TLANFNPQQT IDFLRHHDVH GELTYELKRK IVKQFLDFKL LMEHLDPDEE DEDGDTSANV
     RNKAITALLG GAAASPRNHH TGDSEEDDER SEGEERTPGA SRRGRRTGDS ADLLSANMNE
     SVSALDIIAI HCPKYRDRPQ IARVIQKNSD GYSIHWMAGS YSSTWAEAKK RDGRKLVPWV
     DSIKETDIIY KKITLTSGNK LNHKVAQTLR SLYAAKDRNS S