NIPS1_HUMAN
ID NIPS1_HUMAN Reviewed; 284 AA.
AC Q9BPW8; B2RAY3; O43800;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Protein NipSnap homolog 1;
DE Short=NipSnap1;
GN Name=NIPSNAP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9661659; DOI=10.1016/s0378-1119(98)00098-5;
RA Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.;
RT "Characterization of the human NIPSNAP1 gene from 22q12: a member of a
RT novel gene family.";
RL Gene 212:13-20(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest expression in liver.
CC -!- SIMILARITY: Belongs to the NipSnap family. {ECO:0000305}.
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DR EMBL; AJ001258; CAA04632.1; -; mRNA.
DR EMBL; AK314407; BAG37030.1; -; mRNA.
DR EMBL; CH471095; EAW59813.1; -; Genomic_DNA.
DR EMBL; BC006473; AAH06473.1; -; mRNA.
DR EMBL; BC002371; AAH02371.1; -; mRNA.
DR CCDS; CCDS13860.1; -.
DR RefSeq; NP_001189431.1; NM_001202502.1.
DR RefSeq; NP_003625.2; NM_003634.3.
DR AlphaFoldDB; Q9BPW8; -.
DR SMR; Q9BPW8; -.
DR BioGRID; 114080; 224.
DR IntAct; Q9BPW8; 77.
DR MINT; Q9BPW8; -.
DR STRING; 9606.ENSP00000216121; -.
DR ChEMBL; CHEMBL4295933; -.
DR GlyGen; Q9BPW8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BPW8; -.
DR MetOSite; Q9BPW8; -.
DR PhosphoSitePlus; Q9BPW8; -.
DR BioMuta; NIPSNAP1; -.
DR DMDM; 17380144; -.
DR UCD-2DPAGE; Q9BPW8; -.
DR EPD; Q9BPW8; -.
DR jPOST; Q9BPW8; -.
DR MassIVE; Q9BPW8; -.
DR MaxQB; Q9BPW8; -.
DR PaxDb; Q9BPW8; -.
DR PeptideAtlas; Q9BPW8; -.
DR PRIDE; Q9BPW8; -.
DR ProteomicsDB; 78581; -.
DR Antibodypedia; 24539; 82 antibodies from 26 providers.
DR DNASU; 8508; -.
DR Ensembl; ENST00000216121.12; ENSP00000216121.7; ENSG00000184117.12.
DR GeneID; 8508; -.
DR KEGG; hsa:8508; -.
DR MANE-Select; ENST00000216121.12; ENSP00000216121.7; NM_003634.4; NP_003625.2.
DR UCSC; uc003afx.5; human.
DR CTD; 8508; -.
DR DisGeNET; 8508; -.
DR GeneCards; NIPSNAP1; -.
DR HGNC; HGNC:7827; NIPSNAP1.
DR HPA; ENSG00000184117; Tissue enhanced (liver).
DR MIM; 603249; gene.
DR neXtProt; NX_Q9BPW8; -.
DR OpenTargets; ENSG00000184117; -.
DR PharmGKB; PA31634; -.
DR VEuPathDB; HostDB:ENSG00000184117; -.
DR eggNOG; KOG2883; Eukaryota.
DR GeneTree; ENSGT00950000183018; -.
DR HOGENOM; CLU_053393_1_0_1; -.
DR InParanoid; Q9BPW8; -.
DR OMA; NESSWFR; -.
DR OrthoDB; 1141024at2759; -.
DR PhylomeDB; Q9BPW8; -.
DR TreeFam; TF314501; -.
DR PathwayCommons; Q9BPW8; -.
DR SignaLink; Q9BPW8; -.
DR BioGRID-ORCS; 8508; 17 hits in 1080 CRISPR screens.
DR ChiTaRS; NIPSNAP1; human.
DR GenomeRNAi; 8508; -.
DR Pharos; Q9BPW8; Tbio.
DR PRO; PR:Q9BPW8; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BPW8; protein.
DR Bgee; ENSG00000184117; Expressed in right lobe of liver and 196 other tissues.
DR ExpressionAtlas; Q9BPW8; baseline and differential.
DR Genevisible; Q9BPW8; HS.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0097060; C:synaptic membrane; IEA:Ensembl.
DR GO; GO:0042165; F:neurotransmitter binding; IEA:Ensembl.
DR GO; GO:0019233; P:sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR012577; NIPSNAP.
DR Pfam; PF07978; NIPSNAP; 1.
DR SUPFAM; SSF54909; SSF54909; 2.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..284
FT /note="Protein NipSnap homolog 1"
FT /id="PRO_0000221146"
FT MOD_RES 65
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 66
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 73
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 80
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 143
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 146
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:19608861"
FT MOD_RES 146
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 191
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 193
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 193
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT MOD_RES 279
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O55125"
FT VARIANT 245
FT /note="E -> K (in dbSNP:rs1058646)"
FT /id="VAR_011630"
FT CONFLICT 156
FT /note="S -> T (in Ref. 1; CAA04632)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 284 AA; 33310 MW; E0B3E60082C2CACA CRC64;
MAPRLCSISV TARRLLGGPG PRAGDVASAA AARFYSKDNE GSWFRSLFVH KVDPRKDAHS
TLLSKKETSN LYKIQFHNVK PEYLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD
QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRRERSQMLL SRRNQLLLEF SFWNEPQPRM
GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL
QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ
