NIPS1_MOUSE
ID NIPS1_MOUSE Reviewed; 284 AA.
AC O55125;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein NipSnap homolog 1;
DE Short=NipSnap1;
GN Name=Nipsnap1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9661659; DOI=10.1016/s0378-1119(98)00098-5;
RA Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.;
RT "Characterization of the human NIPSNAP1 gene from 22q12: a member of a
RT novel gene family.";
RL Gene 212:13-20(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 57-65 AND 180-188, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-146 AND LYS-193, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-65; LYS-66; LYS-73; LYS-80;
RP LYS-143; LYS-146; LYS-191; LYS-193 AND LYS-279, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC -!- SIMILARITY: Belongs to the NipSnap family. {ECO:0000305}.
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DR EMBL; AJ001260; CAA04634.1; -; mRNA.
DR EMBL; BC010837; AAH10837.1; -; mRNA.
DR CCDS; CCDS24392.1; -.
DR RefSeq; NP_032724.1; NM_008698.2.
DR AlphaFoldDB; O55125; -.
DR SMR; O55125; -.
DR BioGRID; 201774; 15.
DR IntAct; O55125; 1.
DR STRING; 10090.ENSMUSP00000049338; -.
DR iPTMnet; O55125; -.
DR PhosphoSitePlus; O55125; -.
DR SwissPalm; O55125; -.
DR EPD; O55125; -.
DR jPOST; O55125; -.
DR PaxDb; O55125; -.
DR PeptideAtlas; O55125; -.
DR PRIDE; O55125; -.
DR ProteomicsDB; 293658; -.
DR Antibodypedia; 24539; 82 antibodies from 26 providers.
DR DNASU; 18082; -.
DR Ensembl; ENSMUST00000038570; ENSMUSP00000049338; ENSMUSG00000034285.
DR GeneID; 18082; -.
DR KEGG; mmu:18082; -.
DR UCSC; uc007hvk.1; mouse.
DR CTD; 8508; -.
DR MGI; MGI:1278344; Nipsnap1.
DR VEuPathDB; HostDB:ENSMUSG00000034285; -.
DR eggNOG; KOG2883; Eukaryota.
DR GeneTree; ENSGT00950000183018; -.
DR HOGENOM; CLU_053393_1_0_1; -.
DR InParanoid; O55125; -.
DR OMA; NESSWFR; -.
DR OrthoDB; 1141024at2759; -.
DR PhylomeDB; O55125; -.
DR TreeFam; TF314501; -.
DR BioGRID-ORCS; 18082; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Nipsnap1; mouse.
DR PRO; PR:O55125; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O55125; protein.
DR Bgee; ENSMUSG00000034285; Expressed in saccule of membranous labyrinth and 242 other tissues.
DR ExpressionAtlas; O55125; baseline and differential.
DR Genevisible; O55125; MM.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0097060; C:synaptic membrane; IDA:MGI.
DR GO; GO:0042165; F:neurotransmitter binding; IDA:MGI.
DR GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR012577; NIPSNAP.
DR Pfam; PF07978; NIPSNAP; 1.
DR SUPFAM; SSF54909; SSF54909; 2.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..284
FT /note="Protein NipSnap homolog 1"
FT /id="PRO_0000221147"
FT MOD_RES 65
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 66
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 73
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 80
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BPW8"
FT MOD_RES 143
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 146
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 146
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 191
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 193
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 193
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 279
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
SQ SEQUENCE 284 AA; 33363 MW; E96EA869A58BC3F4 CRC64;
MAPRLCIISA AARRLFTKPR PRAGDLAAAG AVRFYSKDSE GSWFRSLFVH KVDPRKDAHS
TLLSKKETSN LYKIQFHNVK PECLDAYNSL TEAVLPKLHL DEDYPCSLVG NWNTWYGEQD
QAVHLWRFSG GYPALMDCMN KLKNNKEYLE FRKERSKMLL SRRNQLLLEF SFWNEPQPRA
GPNIYELRTY KLKPGTMIEW GNNWARAIKY RQENQEAVGG FFSQIGELYV VHHLWAYKDL
QSREETRNAA WRKRGWDENV YYTVPLVRHM ESRIMIPLKI SPLQ
