ID   NIPS2_MOUSE             Reviewed;         281 AA.
AC   O55126;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Protein NipSnap homolog 2;
DE            Short=NipSnap2;
DE   AltName: Full=Glioblastoma-amplified sequence;
GN   Name=Nipsnap2; Synonyms=Gbas;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9661659; DOI=10.1016/s0378-1119(98)00098-5;
RA   Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.;
RT   "Characterization of the human NIPSNAP1 gene from 22q12: a member of a
RT   novel gene family.";
RL   Gene 212:13-20(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22627147; DOI=10.4161/chan.19415;
RA   Brittain J.M., Wang Y., Wilson S.M., Khanna R.;
RT   "Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.";
RL   Channels 6:94-102(2012).
CC   -!- FUNCTION: May act as a positive regulator of L-type calcium channels.
CC       {ECO:0000269|PubMed:22627147}.
CC   -!- SUBUNIT: Interacts with VDAC1. {ECO:0000250|UniProtKB:O75323}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22627147}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:O75323}.
CC   -!- SIMILARITY: Belongs to the NipSnap family. {ECO:0000305}.
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DR   EMBL; AJ001261; CAA04635.1; -; mRNA.
DR   CCDS; CCDS19698.1; -.
DR   AlphaFoldDB; O55126; -.
DR   IntAct; O55126; 1.
DR   STRING; 10090.ENSMUSP00000083211; -.
DR   iPTMnet; O55126; -.
DR   PhosphoSitePlus; O55126; -.
DR   SwissPalm; O55126; -.
DR   EPD; O55126; -.
DR   jPOST; O55126; -.
DR   MaxQB; O55126; -.
DR   PaxDb; O55126; -.
DR   PeptideAtlas; O55126; -.
DR   PRIDE; O55126; -.
DR   ProteomicsDB; 253075; -.
DR   MGI; MGI:1278343; Nipsnap2.
DR   eggNOG; KOG2883; Eukaryota.
DR   InParanoid; O55126; -.
DR   PhylomeDB; O55126; -.
DR   Reactome; R-MMU-9013407; RHOH GTPase cycle.
DR   Reactome; R-MMU-9013409; RHOJ GTPase cycle.
DR   ChiTaRS; Gbas; mouse.
DR   PRO; PR:O55126; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O55126; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0007005; P:mitochondrion organization; ISO:MGI.
DR   GO; GO:0006119; P:oxidative phosphorylation; ISO:MGI.
DR   GO; GO:1901843; P:positive regulation of high voltage-gated calcium channel activity; IMP:UniProtKB.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR012577; NIPSNAP.
DR   Pfam; PF07978; NIPSNAP; 1.
DR   SUPFAM; SSF54909; SSF54909; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome.
FT   CHAIN           1..281
FT                   /note="Protein NipSnap homolog 2"
FT                   /id="PRO_0000221149"
SQ   SEQUENCE   281 AA;  32933 MW;  260D52675BF1CA7E CRC64;
     MAARVLLARG GLLRPAAQSA FLPGLRTVTS SSHRAREDSW LKSLFVRKVD PRKDAHSNLL
     AKKETSSLYK LQFHNVKPEC LDAYNKICQE VLPKIHEGKQ YPCTLVGTWN TWYGEQDQAV
     HLWRYEGGYP ALTEVMNKLK ENQEFVNFRK ARSDMLLSRK NQLLLEFSFW NEPVPRPGPN
     IYELRSYQLR PGTMIEWGNY WARAIRFRQD SNEAIGGFFS QIGQLYMVDH LWAYRDLQTR
     EDIRNAAWHK HGWEELVYYT VPLIQEMESR IMIPLKTSPL Q