NIPSN_DROME
ID NIPSN_DROME Reviewed; 273 AA.
AC Q9VXK0; A4V4K8; Q9U5W0;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein NipSnap;
GN Name=Nipsnap; ORFNames=CG9212;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-193.
RA Kedra D., Dumanski J.P.;
RT "Cloning of NIPSNAP gene orthologues in Danio rerio and Drosophila
RT melanogaster.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NipSnap family. {ECO:0000305}.
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DR EMBL; AE014298; AAF48562.2; -; Genomic_DNA.
DR EMBL; AE014298; AAN09383.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09384.1; -; Genomic_DNA.
DR EMBL; AY061048; AAL28596.1; -; mRNA.
DR EMBL; AJ249798; CAB56699.1; -; mRNA.
DR RefSeq; NP_001285316.1; NM_001298387.1.
DR RefSeq; NP_573103.1; NM_132875.4.
DR RefSeq; NP_727931.1; NM_167483.3.
DR RefSeq; NP_727932.1; NM_167484.3.
DR AlphaFoldDB; Q9VXK0; -.
DR SMR; Q9VXK0; -.
DR BioGRID; 58917; 7.
DR DIP; DIP-17236N; -.
DR STRING; 7227.FBpp0074034; -.
DR PaxDb; Q9VXK0; -.
DR PRIDE; Q9VXK0; -.
DR DNASU; 32573; -.
DR EnsemblMetazoa; FBtr0074257; FBpp0074034; FBgn0030724.
DR EnsemblMetazoa; FBtr0074258; FBpp0074035; FBgn0030724.
DR EnsemblMetazoa; FBtr0074259; FBpp0074036; FBgn0030724.
DR EnsemblMetazoa; FBtr0343595; FBpp0310192; FBgn0030724.
DR GeneID; 32573; -.
DR KEGG; dme:Dmel_CG9212; -.
DR UCSC; CG9212-RA; d. melanogaster.
DR CTD; 32573; -.
DR FlyBase; FBgn0030724; Nipsnap.
DR VEuPathDB; VectorBase:FBgn0030724; -.
DR eggNOG; KOG2883; Eukaryota.
DR GeneTree; ENSGT00950000183018; -.
DR HOGENOM; CLU_053393_1_0_1; -.
DR InParanoid; Q9VXK0; -.
DR OMA; WPQIASR; -.
DR OrthoDB; 1141024at2759; -.
DR PhylomeDB; Q9VXK0; -.
DR Reactome; R-DME-9013407; RHOH GTPase cycle.
DR BioGRID-ORCS; 32573; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32573; -.
DR PRO; PR:Q9VXK0; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030724; Expressed in Malpighian tubule and 12 other tissues.
DR ExpressionAtlas; Q9VXK0; baseline and differential.
DR Genevisible; Q9VXK0; DM.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; ISS:FlyBase.
DR GO; GO:0006119; P:oxidative phosphorylation; ISS:FlyBase.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR012577; NIPSNAP.
DR Pfam; PF07978; NIPSNAP; 2.
DR SUPFAM; SSF54909; SSF54909; 2.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..273
FT /note="Protein NipSnap"
FT /id="PRO_0000221151"
FT CONFLICT 191..193
FT /note="NNW -> KQT (in Ref. 4; CAB56699)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 31965 MW; 3F7DEBB24670636D CRC64;
MLKLRNLLAV GKSNNNAVRS LSTTPSRNDS ESWFSKLLVR KIEPTKESHS RMLSDKEIIY
ALHTHNVRPD SMGSYLNNYK TTVALINEKK ANLSCELVAS WTVQVGDMDQ CLHLWKYTGG
FEKIDQAKED LWNDPEYLSL MQERSKFLRS RHLQYLLAFS YWPQIASRTG KNIYEMRSYR
LTPGTMIEWG NNWARAINYR KHNNEAFAGF FSQIGRLYNV HHIWCYKSLQ DRKETREAAW
RSPGWDECVA YTVPLIREMH CRVLAPTEFS PSQ