ID   NIRC_SHIFL              Reviewed;         268 AA.
AC   P0AC27; P11097; P78112;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Nitrite transporter NirC;
GN   Name=nirC; OrderedLocusNames=SF3386, S4377;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Catalyzes nitrite uptake and nitrite export across the
CC       cytoplasmic membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FNT transporter (TC 2.A.44) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN44849.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP19329.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN44849.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP19329.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000493556.1; NZ_WPGW01000003.1.
DR   AlphaFoldDB; P0AC27; -.
DR   SMR; P0AC27; -.
DR   STRING; 198214.SF3386; -.
DR   EnsemblBacteria; AAN44849; AAN44849; SF3386.
DR   EnsemblBacteria; AAP19329; AAP19329; S4377.
DR   GeneID; 66672752; -.
DR   KEGG; sfx:S4377; -.
DR   PATRIC; fig|623.156.peg.1849; -.
DR   HOGENOM; CLU_1466086_0_0_6; -.
DR   OrthoDB; 1834167at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000292; For/NO2_transpt.
DR   InterPro; IPR024002; For/NO2_transpt_CS.
DR   PANTHER; PTHR30520; PTHR30520; 1.
DR   Pfam; PF01226; Form_Nir_trans; 1.
DR   TIGRFAMs; TIGR00790; fnt; 1.
DR   PROSITE; PS01005; FORMATE_NITRITE_TP_1; 1.
DR   PROSITE; PS01006; FORMATE_NITRITE_TP_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Nitrate assimilation;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..268
FT                   /note="Nitrite transporter NirC"
FT                   /id="PRO_0000094726"
FT   TOPO_DOM        1..29
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..58
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..107
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..153
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   268 AA;  28563 MW;  6E01788EA8FB8F31 CRC64;
     MFTDTINKCA ANAARIARLS ANNPLGFWVS SAMAGAYVGL GIILIFTLGN LLDPSVRPLV
     MGATFGIALT LVIIAGSELF TGHTMFLTFG VKAGSISHGQ MWAILPQTWL GNLVGSVFVA
     MLYSWGGGSL LPVDTSIVHS VALAKTTAPA MVLFFKGALC NWLVCLAIWM ALRTEGAAKF
     IAIWWCLLAF IASGYEHSIA NMTLFALSWF GNHSEAYTLA GIGHNLLWVT LGNTLSGAVF
     MGLGYWYATP KANRPVADKF NQTETAAG