ID   NIRDL_PARDP             Reviewed;         325 AA.
AC   Q51703; A1B4Y4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Siroheme decarboxylase NirDL subunit {ECO:0000250|UniProtKB:I6UH61};
DE            EC=4.1.1.111 {ECO:0000250|UniProtKB:I6UH61};
GN   Name=nirDL {ECO:0000250|UniProtKB:I6UH61}; OrderedLocusNames=Pden_2491;
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=318586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
RX   PubMed=7747927; DOI=10.1007/bf00871635;
RA   de Boer A.P.N., Reijnders W.N.M., Kuenen J.G., Stouthamer A.H.,
RA   van Spanning R.J.M.;
RT   "Isolation, sequencing and mutational analysis of a gene cluster involved
RT   in nitrite reduction in Paracoccus denitrificans.";
RL   Antonie Van Leeuwenhoek 66:111-127(1994).
CC   -!- FUNCTION: Involved in heme d1 biosynthesis. Catalyzes the
CC       decarboxylation of siroheme into didecarboxysiroheme.
CC       {ECO:0000250|UniProtKB:I6UH61}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2;
CC         Xref=Rhea:RHEA:19093, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:60052, ChEBI:CHEBI:140497; EC=4.1.1.111;
CC         Evidence={ECO:0000250|UniProtKB:I6UH61};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism.
CC       {ECO:0000250|UniProtKB:I6UH61}.
CC   -!- SUBUNIT: Forms a complex composed of NirDL, NirG and NirH. All proteins
CC       are required for the total conversion of siroheme to
CC       didecarboxysiroheme. {ECO:0000250|UniProtKB:I6UH61}.
CC   -!- SIMILARITY: Belongs to the Ahb/Nir family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA93122.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=ABL70578.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000489; ABL70578.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U05002; AAA93122.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; Q51703; -.
DR   SMR; Q51703; -.
DR   STRING; 318586.Pden_2491; -.
DR   PRIDE; Q51703; -.
DR   EnsemblBacteria; ABL70578; ABL70578; Pden_2491.
DR   KEGG; pde:Pden_2491; -.
DR   eggNOG; COG1522; Bacteria.
DR   HOGENOM; CLU_049427_0_0_5; -.
DR   Proteomes; UP000000361; Chromosome 1.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR040523; AsnC_trans_reg2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF17805; AsnC_trans_reg2; 2.
DR   Pfam; PF13404; HTH_AsnC-type; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..325
FT                   /note="Siroheme decarboxylase NirDL subunit"
FT                   /id="PRO_0000021814"
FT   CONFLICT        194
FT                   /note="A -> P (in Ref. 2; AAA93122)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209..214
FT                   /note="LAEARI -> EPRRTS (in Ref. 2; AAA93122)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  35251 MW;  4BEB264F85D266C6 CRC64;
     MTMDDLDLRL LDGFQRDLPL EPRPFAAMAT RLGTGEAEVI ARLVRLRDEG IVSRIGATCR
     PNTAGASTLA ALRVPAPRVD EIAALVGAEP GVNHSYLREG DWNLWFVATA PDTAALAESL
     VRIEAATGLA VLSLPLVRAF NIDLGFPLIG PRRAMALDRP ADLDALRPRD KALMQALSSG
     LALVPRPFVA LGQALHRSEA EVISRIRALA EARILTRVGV IVKHRALGWT QNAMVVWRLP
     EAAVEAAGTA LAGVPGVTLC YQRRCVPGLW DWPLFCMIHA RSHAEAMEVL AEARALPELQ
     EVPHRILFST RCFRQRGATI AEVAA