NISR_LACLL
ID NISR_LACLL Reviewed; 229 AA.
AC Q07597;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Nisin biosynthesis regulatory protein NisR;
GN Name=nisR;
OS Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1360;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NIZO R5;
RX PubMed=8478324; DOI=10.1128/jb.175.9.2578-2588.1993;
RA van der Meer J.R., Polman J., Beerthuyzen M.M., Siezen R.J., Kuipers O.P.,
RA de Vos W.M.;
RT "Characterization of the Lactococcus lactis nisin A operon genes nisP,
RT encoding a subtilisin-like serine protease involved in precursor
RT processing, and nisR, encoding a regulatory protein involved in nisin
RT biosynthesis.";
RL J. Bacteriol. 175:2578-2588(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=6F3;
RX PubMed=8161176; DOI=10.1128/aem.60.3.814-825.1994;
RA Engelke G., Gutowski-Eckel Z., Kiesau P., Siegers K., Hammelmann M.,
RA Entian K.-D.;
RT "Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.";
RL Appl. Environ. Microbiol. 60:814-825(1994).
CC -!- FUNCTION: Member of the two-component regulatory system NisK/NisR
CC involved in the regulation of the biosynthesis of lantibiotic nisin.
CC NisR may function as a regulatory protein.
CC -!- PTM: Phosphorylated by NisK. {ECO:0000305}.
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DR EMBL; Z22813; CAA80466.1; -; Genomic_DNA.
DR EMBL; L11061; AAA25201.1; -; Genomic_DNA.
DR EMBL; X76884; CAA54211.1; -; Genomic_DNA.
DR PIR; B40621; B40621.
DR RefSeq; WP_014734918.1; NZ_LKLI01000093.1.
DR AlphaFoldDB; Q07597; -.
DR SMR; Q07597; -.
DR GeneID; 66441590; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..229
FT /note="Nisin biosynthesis regulatory protein NisR"
FT /id="PRO_0000081151"
FT DOMAIN 4..117
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 132..229
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 2
FT /note="Missing (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 26715 MW; 65212EB7BC7CB477 CRC64;
MVYKILIVDD DQEILKLMKT ALEMRNYEVA THQNISLPLD ITDFQGFDLI LLDIMMSNIE
GTEICKRIRR EISTPIIFVS AKDTEEDIIN GLGIGGDDYI TKPFSLKQLV AKVEANIKRE
ERNKHAVHVF SEIRRDLGPI TFYLEERRVC VNGQTIPLTC REYDILELLS QRTSKVYTRE
DIYDDVYDEY SNALFRSISE YIYQIRSKFA PYDINPIKTV RGLGYQWHG
