NK1R_RAT
ID NK1R_RAT Reviewed; 407 AA.
AC P14600;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Substance-P receptor;
DE Short=SPR;
DE AltName: Full=NK-1 receptor;
DE Short=NK-1R;
DE AltName: Full=Tachykinin receptor 1;
GN Name=Tacr1; Synonyms=Tac1r;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1705552; DOI=10.1016/s0021-9258(20)64331-9;
RA Hershey A.D., Dykema P.E., Krause J.E.;
RT "Organization, structure, and expression of the gene encoding the rat
RT substance P receptor.";
RL J. Biol. Chem. 266:4366-4374(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2478537; DOI=10.1016/s0021-9258(19)84619-7;
RA Yokota Y., Sasai Y., Tanaka K., Fujiwara T., Tsuchida K., Shigemoto R.,
RA Kakizuka A., Ohkubo H., Nakanishi S.;
RT "Molecular characterization of a functional cDNA for rat substance P
RT receptor.";
RL J. Biol. Chem. 264:17649-17652(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=2154852; DOI=10.1126/science.2154852;
RA Hershey A.D., Krause J.E.;
RT "Molecular characterization of a functional cDNA encoding the rat substance
RT P receptor.";
RL Science 247:958-962(1990).
RN [4]
RP SEQUENCE REVISION TO 213.
RA Hershey A.D.;
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC P. It is probably associated with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system. The rank order of
CC affinity of this receptor to tachykinins is: substance P > substance K
CC > neuromedin-K.
CC -!- SUBUNIT: Interacts with ARRB1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M64236; AAA42176.1; -; Genomic_DNA.
DR EMBL; M64232; AAA42176.1; JOINED; Genomic_DNA.
DR EMBL; M64233; AAA42176.1; JOINED; Genomic_DNA.
DR EMBL; M64234; AAA42176.1; JOINED; Genomic_DNA.
DR EMBL; M64235; AAA42176.1; JOINED; Genomic_DNA.
DR EMBL; J05097; AAA42175.1; -; mRNA.
DR EMBL; M31477; AAB59726.1; -; mRNA.
DR PIR; A38692; A34357.
DR RefSeq; NP_036799.1; NM_012667.2.
DR AlphaFoldDB; P14600; -.
DR SMR; P14600; -.
DR BioGRID; 246930; 2.
DR STRING; 10116.ENSRNOP00000007984; -.
DR BindingDB; P14600; -.
DR ChEMBL; CHEMBL4027; -.
DR GuidetoPHARMACOLOGY; 360; -.
DR GlyGen; P14600; 2 sites.
DR PhosphoSitePlus; P14600; -.
DR PaxDb; P14600; -.
DR Ensembl; ENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853.
DR GeneID; 24807; -.
DR KEGG; rno:24807; -.
DR UCSC; RGD:3811; rat.
DR CTD; 6869; -.
DR RGD; 3811; Tacr1.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000153745; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P14600; -.
DR OMA; SYAVHNE; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; P14600; -.
DR TreeFam; TF315303; -.
DR Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:P14600; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000005853; Expressed in duodenum and 9 other tissues.
DR Genevisible; P14600; RN.
DR GO; GO:0044297; C:cell body; IDA:RGD.
DR GO; GO:0071944; C:cell periphery; ISO:RGD.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR GO; GO:0061827; C:sperm head; ISO:RGD.
DR GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR GO; GO:0016496; F:substance P receptor activity; IDA:RGD.
DR GO; GO:0004995; F:tachykinin receptor activity; IBA:GO_Central.
DR GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
DR GO; GO:0002118; P:aggressive behavior; IMP:RGD.
DR GO; GO:0003051; P:angiotensin-mediated drinking behavior; IMP:RGD.
DR GO; GO:0008306; P:associative learning; IMP:RGD.
DR GO; GO:0048266; P:behavioral response to pain; IMP:RGD.
DR GO; GO:0042755; P:eating behavior; IMP:RGD.
DR GO; GO:0007611; P:learning or memory; IMP:RGD.
DR GO; GO:0007616; P:long-term memory; IMP:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; TAS:RGD.
DR GO; GO:0035106; P:operant conditioning; IMP:RGD.
DR GO; GO:0045760; P:positive regulation of action potential; IMP:RGD.
DR GO; GO:0045777; P:positive regulation of blood pressure; IMP:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:RGD.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:RGD.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IMP:RGD.
DR GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IMP:RGD.
DR GO; GO:0045778; P:positive regulation of ossification; IMP:RGD.
DR GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:RGD.
DR GO; GO:0046878; P:positive regulation of saliva secretion; IMP:RGD.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IMP:RGD.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IMP:RGD.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IMP:RGD.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:RGD.
DR GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
DR GO; GO:0008217; P:regulation of blood pressure; IMP:RGD.
DR GO; GO:0014910; P:regulation of smooth muscle cell migration; IMP:RGD.
DR GO; GO:0048660; P:regulation of smooth muscle cell proliferation; IMP:RGD.
DR GO; GO:0070472; P:regulation of uterine smooth muscle contraction; ISO:RGD.
DR GO; GO:0010996; P:response to auditory stimulus; IDA:RGD.
DR GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IMP:RGD.
DR GO; GO:0009408; P:response to heat; IMP:RGD.
DR GO; GO:0009725; P:response to hormone; IMP:RGD.
DR GO; GO:0043278; P:response to morphine; IEP:RGD.
DR GO; GO:0035094; P:response to nicotine; IMP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IDA:RGD.
DR GO; GO:0010193; P:response to ozone; IMP:RGD.
DR GO; GO:0048265; P:response to pain; ISO:RGD.
DR GO; GO:0032570; P:response to progesterone; IEP:RGD.
DR GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
DR GO; GO:0060083; P:smooth muscle contraction involved in micturition; IMP:RGD.
DR GO; GO:0042713; P:sperm ejaculation; IMP:RGD.
DR GO; GO:0007217; P:tachykinin receptor signaling pathway; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000046; NK1_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01024; NEUROKININ1R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..407
FT /note="Substance-P receptor"
FT /id="PRO_0000069888"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 362..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 322
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 73
FT /note="N -> D (in Ref. 3; AAB59726)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 407 AA; 46366 MW; ADF885A0BF551C96 CRC64;
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN VVVIWIILAH
KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY GLFYCKFHNF FPIAALFASI
YSMTAVAFDR YMAIIHPLQP RLSATATKVV IFVIWVLALL LAFPQGYYST TETMPSRVVC
MIEWPEHPNR TYEKAYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV
SAKRKVVKMM IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK VSRLETTIST
VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS FYSNMLA
