NK2R_MESAU
ID NK2R_MESAU Reviewed; 384 AA.
AC P51144;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Substance-K receptor;
DE Short=SKR;
DE AltName: Full=NK-2 receptor;
DE Short=NK-2R;
DE AltName: Full=Neurokinin A receptor;
DE AltName: Full=Tachykinin receptor 2;
GN Name=TACR2; Synonyms=TAC2R;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Urinary bladder;
RX PubMed=8302285;
RA Aharony D., Little J., Thomas C., Powell S., Berry D., Graham A.;
RT "Isolation and pharmacological characterization of a hamster urinary
RT bladder neurokinin A receptor cDNA.";
RL Mol. Pharmacol. 45:9-19(1994).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC K (neurokinin A). It is associated with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system. The rank order of
CC affinity of this receptor to tachykinins is: substance K > neuromedin-K
CC > substance P.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; S68899; AAC60680.1; -; mRNA.
DR RefSeq; XP_005070883.1; XM_005070826.2.
DR AlphaFoldDB; P51144; -.
DR SMR; P51144; -.
DR STRING; 10036.XP_005070883.1; -.
DR BindingDB; P51144; -.
DR ChEMBL; CHEMBL2304405; -.
DR GeneID; 101839819; -.
DR CTD; 6865; -.
DR eggNOG; KOG4219; Eukaryota.
DR OrthoDB; 715197at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061827; C:sperm head; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0004995; F:tachykinin receptor activity; IEA:InterPro.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0070472; P:regulation of uterine smooth muscle contraction; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000913; NK2_rcpt.
DR PANTHER; PTHR46925:SF3; PTHR46925:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01025; NEUROKININ2R.
DR PRINTS; PR00244; NEUROKININR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..384
FT /note="Substance-K receptor"
FT /id="PRO_0000069894"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 324
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 384 AA; 43418 MW; 524BECFC3D0067F3 CRC64;
MGGRAIVTDT NIFSGLESNT TGVTAFSMPA WQLALWATAY LGLVLVAVTG NATVIWIILA
HERMRTVTNY FIINLALADL CMAAFNATFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS
IYSMTAIAAD RYMAIVHPFQ PRLSAPITKA TIAGIWLVAL ALASPQCFYS TITVDQGATK
CVVAWPNDNG GKMLLLYHLV VFVLVYFLPL VVMFVAYSVI GLTLWKRAVP RHQAHGANLR
HLHAKKKFVK AMVLVVLTFA ICWLPYHLYF ILGSFQKDIY YRKFIQQVYL ALFWLAMSST
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDRLELTR TPSLSRRVNR CHTKETLFMT
ADMTHSEATN GQVGSPQDVE PAAP
