NK2R_MOUSE
ID NK2R_MOUSE Reviewed; 384 AA.
AC P30549;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Substance-K receptor;
DE Short=SKR;
DE AltName: Full=NK-2 receptor;
DE Short=NK-2R;
DE AltName: Full=Neurokinin A receptor;
DE AltName: Full=Tachykinin receptor 2;
GN Name=Tacr2; Synonyms=Tac2r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=1370937; DOI=10.1111/j.1432-1033.1992.tb16592.x;
RA Sundelin J.B., Provvedini D.M., Wahlestedt C.R., Laurell H., Pohl J.S.,
RA Peterson P.A.;
RT "Molecular cloning of the murine substance K and substance P receptor
RT genes.";
RL Eur. J. Biochem. 203:625-631(1992).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC K (neurokinin A). It is associated with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system. The rank order of
CC affinity of this receptor to tachykinins is: substance K > neuromedin-K
CC > substance P.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X62933; CAA44706.1; -; mRNA.
DR CCDS; CCDS35919.1; -.
DR PIR; S20303; S20303.
DR RefSeq; NP_033340.3; NM_009314.4.
DR AlphaFoldDB; P30549; -.
DR SMR; P30549; -.
DR STRING; 10090.ENSMUSP00000020278; -.
DR BindingDB; P30549; -.
DR ChEMBL; CHEMBL2813; -.
DR GlyGen; P30549; 1 site.
DR iPTMnet; P30549; -.
DR PhosphoSitePlus; P30549; -.
DR PaxDb; P30549; -.
DR PRIDE; P30549; -.
DR Antibodypedia; 1518; 310 antibodies from 36 providers.
DR DNASU; 21337; -.
DR Ensembl; ENSMUST00000020278; ENSMUSP00000020278; ENSMUSG00000020081.
DR GeneID; 21337; -.
DR KEGG; mmu:21337; -.
DR UCSC; uc007fgx.2; mouse.
DR CTD; 6865; -.
DR MGI; MGI:98477; Tacr2.
DR VEuPathDB; HostDB:ENSMUSG00000020081; -.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000155512; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P30549; -.
DR OMA; RRVNRCH; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; P30549; -.
DR TreeFam; TF315303; -.
DR Reactome; R-MMU-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 21337; 0 hits in 71 CRISPR screens.
DR PRO; PR:P30549; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P30549; protein.
DR Bgee; ENSMUSG00000020081; Expressed in kidney vasculature and 23 other tissues.
DR ExpressionAtlas; P30549; baseline and differential.
DR Genevisible; P30549; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0036126; C:sperm flagellum; ISO:MGI.
DR GO; GO:0061827; C:sperm head; ISO:MGI.
DR GO; GO:0097225; C:sperm midpiece; ISO:MGI.
DR GO; GO:0016497; F:substance K receptor activity; ISO:MGI.
DR GO; GO:0004995; F:tachykinin receptor activity; IBA:GO_Central.
DR GO; GO:0014827; P:intestine smooth muscle contraction; ISO:MGI.
DR GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; ISO:MGI.
DR GO; GO:0035106; P:operant conditioning; ISO:MGI.
DR GO; GO:0014057; P:positive regulation of acetylcholine secretion, neurotransmission; ISO:MGI.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:MGI.
DR GO; GO:0043270; P:positive regulation of ion transport; ISO:MGI.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; ISO:MGI.
DR GO; GO:0043117; P:positive regulation of vascular permeability; ISO:MGI.
DR GO; GO:0070459; P:prolactin secretion; ISO:MGI.
DR GO; GO:0070472; P:regulation of uterine smooth muscle contraction; IDA:CACAO.
DR GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000913; NK2_rcpt.
DR PANTHER; PTHR46925:SF3; PTHR46925:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01025; NEUROKININ2R.
DR PRINTS; PR00244; NEUROKININR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..384
FT /note="Substance-K receptor"
FT /id="PRO_0000069895"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 324
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 384 AA; 43114 MW; 7937F05A2BB90759 CRC64;
MGAHASVTDT NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA
HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGSTFCYFQN LFPVTAMFVS
IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAVIWLVAL ALASPQCFYS TITVDQGATK
CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL VVMFAAYSVI GLTLWKRAVP RHQAHGANLR
HLQAKKKFVK AMVLVVVTFA ICWLPYHLYF ILGTFQEDIY YRKFIQQVYL ALFWLAMSST
MYNPIIYCCL NHRFRSGFRL AFRCCPWGTP TEEDRLELTH TPSISRRVNR CHTKETLFMT
GDMTHSEATN GQVGGPQDGE PAGP
