NK2R_RABIT
ID NK2R_RABIT Reviewed; 384 AA.
AC P79218;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Substance-K receptor;
DE Short=SKR;
DE AltName: Full=NK-2 receptor;
DE Short=NK-2R;
DE AltName: Full=Neurokinin A receptor;
DE AltName: Full=Tachykinin receptor 2;
GN Name=TACR2; Synonyms=TAC2R;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pulmonary artery;
RX PubMed=7877137; DOI=10.3109/10799899409101512;
RA Aharony D., Little J., Thomas C., Powell S., Downey-Jones M., Graham A.;
RT "Isolation and characterization of neurokinin A receptor cDNAs from guinea-
RT pig lung and rabbit pulmonary artery.";
RL J. Recept. Res. 14:399-421(1994).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC K (neurokinin A). It is associated with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; S82448; AAB46747.1; -; mRNA.
DR RefSeq; NP_001075800.1; NM_001082331.1.
DR AlphaFoldDB; P79218; -.
DR SMR; P79218; -.
DR STRING; 9986.ENSOCUP00000025353; -.
DR BindingDB; P79218; -.
DR ChEMBL; CHEMBL3433; -.
DR Ensembl; ENSOCUT00000026968; ENSOCUP00000025353; ENSOCUG00000006707.
DR GeneID; 100009175; -.
DR KEGG; ocu:100009175; -.
DR CTD; 6865; -.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000155512; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P79218; -.
DR OMA; RRVNRCH; -.
DR OrthoDB; 715197at2759; -.
DR TreeFam; TF315303; -.
DR PRO; PR:P79218; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000006707; Expressed in uterus and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061827; C:sperm head; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0004995; F:tachykinin receptor activity; IEA:InterPro.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0070472; P:regulation of uterine smooth muscle contraction; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000913; NK2_rcpt.
DR PANTHER; PTHR46925:SF3; PTHR46925:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01025; NEUROKININ2R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..384
FT /note="Substance-K receptor"
FT /id="PRO_0000069896"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 324
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 384 AA; 43128 MW; F35850DF224BF9E9 CRC64;
MGACDIVTEA NISSDIDSNA TGVTAFSMPG WQLALWATAY LALVLVAVVG NATVIWIILA
HRRMRTVTNY FIVNLALADL CMATFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS
IYSMTAIAAD RYMAIVHPFQ PRLSGPGTKA VIAGIWLVAL ALAFPQCFYS TITMDQGATK
CVVAWPEDSG GKMLLLYHLT VIALIYFLPL VVMFVAYSVI GFKLWRRTVP GHQTHGANLR
HLRAKKKFVK TMVLVVVTFA VCWLPYHLYF LLGHFQDDIY CRKFIQQVYL VLFWLAMSST
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDKLELTH TPSLSVRVNR CHTKETLFLV
GDVAPSEAAN GQAGGPQDGG AYDF
