NK2R_RAT
ID NK2R_RAT Reviewed; 390 AA.
AC P16610;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Substance-K receptor;
DE Short=SKR;
DE AltName: Full=NK-2 receptor;
DE Short=NK-2R;
DE AltName: Full=Neurokinin A receptor;
DE AltName: Full=Tachykinin receptor 2;
GN Name=Tacr2; Synonyms=Tac2r;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2480781; DOI=10.1016/s0006-291x(89)80022-1;
RA Sasai Y., Nakanishi S.;
RT "Molecular characterization of rat substance K receptor and its mRNAs.";
RL Biochem. Biophys. Res. Commun. 165:695-702(1989).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide substance
CC K (neurokinin A). It is associated with G proteins that activate a
CC phosphatidylinositol-calcium second messenger system. The rank order of
CC affinity of this receptor to tachykinins is: substance K > neuromedin-K
CC > substance P.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; M31838; AAA42150.1; -; mRNA.
DR PIR; A36737; A36737.
DR RefSeq; NP_542946.1; NM_080768.1.
DR AlphaFoldDB; P16610; -.
DR SMR; P16610; -.
DR STRING; 10116.ENSRNOP00000067266; -.
DR BindingDB; P16610; -.
DR ChEMBL; CHEMBL4554; -.
DR GuidetoPHARMACOLOGY; 361; -.
DR GlyGen; P16610; 1 site.
DR iPTMnet; P16610; -.
DR PhosphoSitePlus; P16610; -.
DR PaxDb; P16610; -.
DR Ensembl; ENSRNOT00000071394; ENSRNOP00000067266; ENSRNOG00000050658.
DR GeneID; 25007; -.
DR KEGG; rno:25007; -.
DR CTD; 6865; -.
DR RGD; 3812; Tacr2.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000155512; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P16610; -.
DR OMA; RRVNRCH; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; P16610; -.
DR Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P16610; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000050658; Expressed in colon and 7 other tissues.
DR Genevisible; P16610; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR GO; GO:0061827; C:sperm head; ISO:RGD.
DR GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR GO; GO:0016497; F:substance K receptor activity; IDA:RGD.
DR GO; GO:0004995; F:tachykinin receptor activity; IBA:GO_Central.
DR GO; GO:0014827; P:intestine smooth muscle contraction; IMP:RGD.
DR GO; GO:0033685; P:negative regulation of luteinizing hormone secretion; IMP:RGD.
DR GO; GO:0035106; P:operant conditioning; IMP:RGD.
DR GO; GO:0014057; P:positive regulation of acetylcholine secretion, neurotransmission; IMP:RGD.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:RGD.
DR GO; GO:0043270; P:positive regulation of ion transport; IMP:RGD.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:RGD.
DR GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
DR GO; GO:0070459; P:prolactin secretion; IMP:RGD.
DR GO; GO:0070472; P:regulation of uterine smooth muscle contraction; ISO:RGD.
DR GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000913; NK2_rcpt.
DR PANTHER; PTHR46925:SF3; PTHR46925:SF3; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01025; NEUROKININ2R.
DR PRINTS; PR00244; NEUROKININR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..390
FT /note="Substance-K receptor"
FT /id="PRO_0000069897"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..390
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 324
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 390 AA; 43853 MW; A6C4FF70194726DB CRC64;
MGTRAIVSDA NILSGLESNA TGVTAFSMPG WQLALWATAY LALVLVAVTG NATVIWIILA
HERMRTVTNY FIINLALADL CMAAFNATFN FIYASHNIWY FGRAFCYFQN LFPITAMFVS
IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA IIAGIWLVAL ALASPQCFYS TITVDEGATK
CVVAWPNDNG GKMLLLYHLV VFVLIYFLPL LVMFGAYSVI GLTLWKRAVP RHQAHGANLR
HLQAKKKFVK AMVLVVLTFA ICWLPYHLYF ILGTFQEDIY YHKFIQQVYL ALFWLAMSST
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TEEDRLELTH TPSLSRRVNR CHTKETLFMT
GDMTHSEATN GQVGSPQDGE PAGPICKAQA
