NK3R_CAVPO
ID NK3R_CAVPO Reviewed; 440 AA.
AC P30098; Q925R4;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Neuromedin-K receptor;
DE Short=NKR;
DE AltName: Full=NK-3 receptor;
DE Short=NK-3R;
DE AltName: Full=Neurokinin B receptor;
DE AltName: Full=Tachykinin receptor 3;
GN Name=TACR3;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=1315051; DOI=10.1073/pnas.89.9.4124;
RA Xie G.-X., Miyajima A., Goldstein A.;
RT "Expression cloning of cDNA encoding a seven-helix receptor from human
RT placenta with affinity for opioid ligands.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:4124-4128(1992).
RN [2]
RP SHOWS THAT IT IS NOT AN OPIOID RECEPTOR.
RX PubMed=8947459; DOI=10.1042/bj3200001;
RA Donaldson L.F., Haskell C.A., Hanley M.R.;
RT "Functional characterization by heterologous expression of a novel cloned
RT tachykinin peptide receptor.";
RL Biochem. J. 320:1-5(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SHOWS THAT IT IS NOT A HUMAN SEQUENCE.
RX PubMed=11864635; DOI=10.1016/s0014-2999(02)01278-5;
RA Page N.M., Bell N.J.;
RT "The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a
RT reappraisal.";
RL Eur. J. Pharmacol. 437:27-30(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Stumm R.K., Derst C., Schaefer M.K.H., Weihe E.;
RT "Cloning and sequencing of guinea pig NK3 receptor.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide
CC neuromedin-K (neurokinin B). It is associated with G proteins that
CC activate a phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: The anchoring of this receptor to the plasma membrane is probably
CC mediated by the palmitoylation of a cysteine residue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was originally (PubMed:1315051) thought to be a kappa-type
CC opioid receptor and to originate from human. PubMed:8947459 showed that
CC it is a tachikinin receptor and was termed NK-4R. PubMed:11864635 shows
CC that it is from guinea pig and is NK-3R. {ECO:0000305|PubMed:1315051}.
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DR EMBL; M84605; AAA36395.1; -; mRNA.
DR EMBL; AF426173; AAL78507.1; -; mRNA.
DR EMBL; AF255393; AAK49193.1; -; mRNA.
DR PIR; A44081; A44081.
DR RefSeq; NP_001166200.1; NM_001172729.1.
DR AlphaFoldDB; P30098; -.
DR SMR; P30098; -.
DR STRING; 10141.ENSCPOP00000014870; -.
DR BindingDB; P30098; -.
DR ChEMBL; CHEMBL3799; -.
DR GeneID; 100135627; -.
DR KEGG; cpoc:100135627; -.
DR CTD; 6870; -.
DR eggNOG; KOG4219; Eukaryota.
DR InParanoid; P30098; -.
DR OrthoDB; 715197at2759; -.
DR PRO; PR:P30098; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0004995; F:tachykinin receptor activity; TAS:ProtInc.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR001013; NK3_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01026; NEUROKININ3R.
DR PRINTS; PR00244; NEUROKININR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..440
FT /note="Neuromedin-K receptor"
FT /id="PRO_0000069898"
FT TOPO_DOM 1..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..82
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..156
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..245
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..440
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 22..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 349
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 133..208
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 59
FT /note="A -> R (in Ref. 4; AAK49193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 49432 MW; 544EB3A71CC6C143 CRC64;
MASPAGNLSA WPGWGWPPPA ALRNLTSSPA PTASPSPAPS WTPSPRPGPA HPFLQPPWAV
ALWSLAYGAV VAVAVLGNLV VIWIVLAHKR MRTVTNSFLV NLAFADAAMA ALNALVNFIY
ALHGEWYFGA NYCRFQNFFP ITAVFASIYS MTAIAVDRYM AIIDPLKPRL SATATRIVIG
SIWILAFLLA FPQCLYSKIK VMPGRTLCYV QWPEGSRQHF TYHMIVIVLV YCFPLLIMGI
TYTIVGITLW GGEIPGDTCD KYQEQLKAKR KVVKMMIIVV VTFAICWLPY HIYFILTAIY
QQLNRWKYIQ QVYLASFWLA MSSTMYNPII YCCLNKRFRA GFKRAFRWCP FIHVSSYDEL
ELKATRLHPM RQSSLYTVTR MESMSVVFDS NDGDSARSSH QKRGTTRDVG SNVCSRRNSK
STSTTASFVS SSHMSVEEGS
