NK3R_MOUSE
ID NK3R_MOUSE Reviewed; 452 AA.
AC P47937; Q61968; Q8BL44; Q9JKN0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Neuromedin-K receptor;
DE Short=NKR;
DE AltName: Full=NK-3 receptor;
DE Short=NK-3R;
DE AltName: Full=Neurokinin B receptor;
DE AltName: Full=Tachykinin receptor 3;
GN Name=Tacr3; Synonyms=Tac3r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Feild J.A., Brun K.A.;
RT "Molecular cloning and characterization of the murine neurokinin-3
RT receptor.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-385.
RC TISSUE=Brain;
RA Maroteaux L.;
RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 103-328.
RC STRAIN=CBA/J; TISSUE=Brain;
RX PubMed=8120392;
RA Cook G.A., Elliott D., Metwali A., Blum A.M., Sandor M., Lynch R.,
RA Weinstock J.V.;
RT "Molecular evidence that granuloma T lymphocytes in murine schistosomiasis
RT mansoni express an authentic substance P (NK-1) receptor.";
RL J. Immunol. 152:1830-1835(1994).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide
CC neuromedin-K (neurokinin B). It is associated with G proteins that
CC activate a phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: The anchoring of this receptor to the plasma membrane is probably
CC mediated by the palmitoylation of a cysteine residue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF233341; AAF62517.1; -; mRNA.
DR EMBL; AK031898; BAC27596.1; -; mRNA.
DR EMBL; AK046424; BAC32723.1; -; mRNA.
DR EMBL; X87823; CAA61088.1; -; mRNA.
DR EMBL; L27827; AAA17893.1; -; mRNA.
DR CCDS; CCDS17852.1; -.
DR PIR; S55524; S55524.
DR RefSeq; NP_067357.1; NM_021382.6.
DR AlphaFoldDB; P47937; -.
DR SMR; P47937; -.
DR STRING; 10090.ENSMUSP00000029822; -.
DR BindingDB; P47937; -.
DR GuidetoPHARMACOLOGY; 362; -.
DR GlyGen; P47937; 4 sites.
DR iPTMnet; P47937; -.
DR PhosphoSitePlus; P47937; -.
DR PaxDb; P47937; -.
DR PRIDE; P47937; -.
DR ProteomicsDB; 253076; -.
DR Antibodypedia; 1543; 370 antibodies from 34 providers.
DR Ensembl; ENSMUST00000029822; ENSMUSP00000029822; ENSMUSG00000028172.
DR GeneID; 21338; -.
DR KEGG; mmu:21338; -.
DR UCSC; uc008rky.2; mouse.
DR CTD; 6870; -.
DR MGI; MGI:892968; Tacr3.
DR VEuPathDB; HostDB:ENSMUSG00000028172; -.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000153745; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P47937; -.
DR OMA; PQCLYSI; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; P47937; -.
DR TreeFam; TF315303; -.
DR Reactome; R-MMU-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 21338; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tacr3; mouse.
DR PRO; PR:P47937; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P47937; protein.
DR Bgee; ENSMUSG00000028172; Expressed in iris and 145 other tissues.
DR Genevisible; P47937; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0032590; C:dendrite membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097225; C:sperm midpiece; ISO:MGI.
DR GO; GO:0004995; F:tachykinin receptor activity; ISO:MGI.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0042538; P:hyperosmotic salinity response; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:MGI.
DR GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; ISO:MGI.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; ISO:MGI.
DR GO; GO:0060259; P:regulation of feeding behavior; ISO:MGI.
DR GO; GO:0042220; P:response to cocaine; ISO:MGI.
DR GO; GO:0032355; P:response to estradiol; ISO:MGI.
DR GO; GO:0043278; P:response to morphine; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR001013; NK3_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01026; NEUROKININ3R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..452
FT /note="Neuromedin-K receptor"
FT /id="PRO_0000069900"
FT TOPO_DOM 1..71
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..94
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..126
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..257
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..346
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 401..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 361
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 145..220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 59
FT /note="A -> D (in Ref. 3; CAA61088)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="A -> S (in Ref. 4; AAA17893)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="P -> L (in Ref. 3; CAA61088)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="S -> P (in Ref. 3; CAA61088)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 452 AA; 51026 MW; 7A46D400AD7FC444 CRC64;
MASVPTGENW TDGTAGVGSH TGNLSAALGI TEWLALQAGN FSSALGLPVT SQAPSQVRAN
LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH KRMRTVTNYF LVNLAFSDAS
VAAFNTLVNF IYGVHSEWYF GANYCRFQNF FPITAVFASI YSMTAIAVDR YMAIIDPLKP
RLSATATKIV IGSIWILAFL LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII
LVYCFPLLIM GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF RAGFKRAFRW
CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLY DPSEGDPAKS SRKKRAVPRD
PSANGCSHRE FKSASTTSSF ISSPYTSVDE YS
