NK3R_RAT
ID NK3R_RAT Reviewed; 452 AA.
AC P16177;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Neuromedin-K receptor;
DE Short=NKR;
DE AltName: Full=NK-3 receptor;
DE Short=NK-3R;
DE AltName: Full=Neurokinin B receptor;
DE AltName: Full=Tachykinin receptor 3;
GN Name=Tacr3; Synonyms=Tac3r;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=2153106; DOI=10.1016/s0021-9258(19)40095-1;
RA Shigemoto R., Yokota Y., Tsuchida K., Nakanishi S.;
RT "Cloning and expression of a rat neuromedin K receptor cDNA.";
RL J. Biol. Chem. 265:623-628(1990).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide
CC neuromedin-K (neurokinin B). It is associated with G proteins that
CC activate a phosphatidylinositol-calcium second messenger system. The
CC rank order of affinity of this receptor to tachykinins is: neuromedin-K
CC > substance K > substance P.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: The anchoring of this receptor to the plasma membrane is probably
CC mediated by the palmitoylation of a cysteine residue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; J05189; AAA41688.1; -; mRNA.
DR PIR; A34916; A34916.
DR RefSeq; NP_058749.1; NM_017053.1.
DR AlphaFoldDB; P16177; -.
DR SMR; P16177; -.
DR STRING; 10116.ENSRNOP00000012473; -.
DR BindingDB; P16177; -.
DR ChEMBL; CHEMBL3154; -.
DR GuidetoPHARMACOLOGY; 362; -.
DR GlyGen; P16177; 4 sites.
DR PhosphoSitePlus; P16177; -.
DR PaxDb; P16177; -.
DR Ensembl; ENSRNOT00000012473; ENSRNOP00000012473; ENSRNOG00000009372.
DR GeneID; 24808; -.
DR KEGG; rno:24808; -.
DR CTD; 6870; -.
DR RGD; 3810; Tacr3.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000153745; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR InParanoid; P16177; -.
DR OMA; PQCLYSI; -.
DR OrthoDB; 715197at2759; -.
DR PhylomeDB; P16177; -.
DR TreeFam; TF315303; -.
DR Reactome; R-RNO-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P16177; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000009372; Expressed in frontal cortex and 7 other tissues.
DR Genevisible; P16177; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0032590; C:dendrite membrane; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:RGD.
DR GO; GO:0032809; C:neuronal cell body membrane; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR GO; GO:0004995; F:tachykinin receptor activity; IDA:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0042538; P:hyperosmotic salinity response; IDA:RGD.
DR GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISO:RGD.
DR GO; GO:0010460; P:positive regulation of heart rate; IDA:RGD.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:RGD.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; IDA:RGD.
DR GO; GO:0060259; P:regulation of feeding behavior; IDA:RGD.
DR GO; GO:0042220; P:response to cocaine; IMP:RGD.
DR GO; GO:0032355; P:response to estradiol; IDA:RGD.
DR GO; GO:0043278; P:response to morphine; IEP:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR001013; NK3_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01026; NEUROKININ3R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..452
FT /note="Neuromedin-K receptor"
FT /id="PRO_0000069902"
FT TOPO_DOM 1..71
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..94
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..126
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..168
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..257
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..346
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 400..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 361
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 145..220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 452 AA; 51107 MW; 51D8EFC94F34CCAE CRC64;
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT TQAPSQVRAN
LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH KRMRTVTNYF LVNLAFSDAS
VAAFNTLINF IYGLHSEWYF GANYCRFQNF FPITAVFASI YSMTAIAVDR YMAIIDPLKP
RLSATATKIV IGSIWILAFL LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII
LVYCFPLLIM GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF RAGFKRAFRW
CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF DPNDGDPTKS SRKKRAVPRD
PSANGCSHRG SKSASTTSSF ISSPYTSVDE YS
