NKAI1_MOUSE
ID NKAI1_MOUSE Reviewed; 207 AA.
AC Q9D035; A6MHP4; Q9D0Q6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1;
DE Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1;
DE AltName: Full=Protein FAM77C;
GN Name=Nkain1; Synonyms=Fam77c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ATP1B1, AND TISSUE
RP SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=17606467; DOI=10.1093/hmg/ddm167;
RA Gorokhova S., Bibert S., Geering K., Heintz N.;
RT "A novel family of transmembrane proteins interacting with beta subunits of
RT the Na,K-ATPase.";
RL Hum. Mol. Genet. 16:2394-2410(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with ATP1B1 C-terminus.
CC {ECO:0000269|PubMed:17606467}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in the brain only and specifically in
CC neurons. Expressed in multiple regions such as cerebral cortex,
CC thalamus, hippocampus, olfactory bulb and brainstem as well as in
CC cerebellum with high expression in granular cell layer.
CC {ECO:0000269|PubMed:17606467}.
CC -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
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DR EMBL; EF058048; ABN51166.1; -; mRNA.
DR EMBL; AK011164; BAB27441.1; -; mRNA.
DR EMBL; AK011850; BAB27879.1; -; mRNA.
DR EMBL; BC116391; AAI16392.1; -; mRNA.
DR CCDS; CCDS57302.1; -.
DR RefSeq; NP_080274.2; NM_025998.3.
DR AlphaFoldDB; Q9D035; -.
DR STRING; 10090.ENSMUSP00000101614; -.
DR GlyGen; Q9D035; 1 site.
DR iPTMnet; Q9D035; -.
DR PhosphoSitePlus; Q9D035; -.
DR MaxQB; Q9D035; -.
DR PaxDb; Q9D035; -.
DR PRIDE; Q9D035; -.
DR ProteomicsDB; 253077; -.
DR Antibodypedia; 16738; 80 antibodies from 16 providers.
DR Ensembl; ENSMUST00000105993; ENSMUSP00000101614; ENSMUSG00000078532.
DR GeneID; 67149; -.
DR KEGG; mmu:67149; -.
DR UCSC; uc008uzi.2; mouse.
DR CTD; 79570; -.
DR MGI; MGI:1914399; Nkain1.
DR VEuPathDB; HostDB:ENSMUSG00000078532; -.
DR eggNOG; KOG4556; Eukaryota.
DR GeneTree; ENSGT00940000159949; -.
DR HOGENOM; CLU_090781_0_0_1; -.
DR InParanoid; Q9D035; -.
DR OMA; KYLIMYA; -.
DR OrthoDB; 1281511at2759; -.
DR PhylomeDB; Q9D035; -.
DR TreeFam; TF321348; -.
DR BioGRID-ORCS; 67149; 1 hit in 60 CRISPR screens.
DR ChiTaRS; Nkain1; mouse.
DR PRO; PR:Q9D035; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D035; protein.
DR Bgee; ENSMUSG00000078532; Expressed in embryonic brain and 113 other tissues.
DR ExpressionAtlas; Q9D035; baseline and differential.
DR Genevisible; Q9D035; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0051117; F:ATPase binding; IPI:MGI.
DR GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR InterPro; IPR008516; Na/K-Atpase_Interacting.
DR PANTHER; PTHR13084; PTHR13084; 1.
DR Pfam; PF05640; NKAIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..207
FT /note="Sodium/potassium-transporting ATPase subunit beta-1-
FT interacting protein 1"
FT /id="PRO_0000263644"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 207 AA; 23551 MW; 52083EAC7A364E2A CRC64;
MGKCSGRCTL VAFCCLQLVA ALQRQIFDFL GYQWAPILAN FLHIMAVILG IFGTVQYRSR
YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN TSLHRSWWME NGPGCLVTPV
LNSRLALEDH HVISVTGCLL DYPYIEALSS ALQIFLALFG FVFACYVSKV FLEEEDSFDF
IGGFDSYGYQ APQKTSHLQL QPLYTSG
