NKAI3_HUMAN
ID NKAI3_HUMAN Reviewed; 197 AA.
AC Q8N8D7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3;
DE Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3;
DE AltName: Full=Protein FAM77D;
GN Name=NKAIN3; Synonyms=FAM77D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
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DR EMBL; AK096949; BAC04909.1; -; mRNA.
DR AlphaFoldDB; Q8N8D7; -.
DR SMR; Q8N8D7; -.
DR BioGRID; 130325; 53.
DR STRING; 9606.ENSP00000429073; -.
DR TCDB; 8.A.118.1.4; the na+k+-atpase beta-subunit interacting nkain (nkain) family.
DR PhosphoSitePlus; Q8N8D7; -.
DR BioMuta; NKAIN3; -.
DR DMDM; 74729419; -.
DR MassIVE; Q8N8D7; -.
DR PaxDb; Q8N8D7; -.
DR PeptideAtlas; Q8N8D7; -.
DR PRIDE; Q8N8D7; -.
DR ProteomicsDB; 72403; -.
DR Antibodypedia; 63542; 10 antibodies from 6 providers.
DR DNASU; 286183; -.
DR Ensembl; ENST00000523211.5; ENSP00000429073.1; ENSG00000185942.13.
DR UCSC; uc010lyq.2; human.
DR GeneCards; NKAIN3; -.
DR HGNC; HGNC:26829; NKAIN3.
DR HPA; ENSG00000185942; Tissue enriched (brain).
DR MIM; 612872; gene.
DR neXtProt; NX_Q8N8D7; -.
DR OpenTargets; ENSG00000185942; -.
DR PharmGKB; PA162397582; -.
DR VEuPathDB; HostDB:ENSG00000185942; -.
DR eggNOG; KOG4556; Eukaryota.
DR GeneTree; ENSGT00940000161484; -.
DR HOGENOM; CLU_090781_0_1_1; -.
DR InParanoid; Q8N8D7; -.
DR OrthoDB; 1281511at2759; -.
DR PhylomeDB; Q8N8D7; -.
DR TreeFam; TF321348; -.
DR PathwayCommons; Q8N8D7; -.
DR SignaLink; Q8N8D7; -.
DR ChiTaRS; NKAIN3; human.
DR Pharos; Q8N8D7; Tdark.
DR PRO; PR:Q8N8D7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8N8D7; protein.
DR Bgee; ENSG00000185942; Expressed in ventricular zone and 117 other tissues.
DR ExpressionAtlas; Q8N8D7; baseline and differential.
DR Genevisible; Q8N8D7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR InterPro; IPR008516; Na/K-Atpase_Interacting.
DR PANTHER; PTHR13084; PTHR13084; 1.
DR Pfam; PF05640; NKAIN; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..197
FT /note="Sodium/potassium-transporting ATPase subunit beta-1-
FT interacting protein 3"
FT /id="PRO_0000263093"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 140
FT /note="V -> I (in dbSNP:rs4739003)"
FT /id="VAR_029583"
SQ SEQUENCE 197 AA; 22620 MW; 1891A3188A9296DC CRC64;
MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR
YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP
PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC
DLQVCKHLFI QMLQIIE
