NKD1_DANRE
ID NKD1_DANRE Reviewed; 440 AA.
AC Q2TJA6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein naked cuticle homolog 1;
DE Short=Naked-1;
GN Name=nkd1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Van Raay T.J., Coffey R.J., Solnica-Krezel L.;
RT "Zebrafish Naked 1 homolog.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling
CC pathway. May activate a second Wnt signaling pathway that controls
CC planar cell polarity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NKD family. {ECO:0000305}.
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DR EMBL; AY863053; AAX55756.1; -; mRNA.
DR RefSeq; NP_001036798.1; NM_001043333.1.
DR AlphaFoldDB; Q2TJA6; -.
DR STRING; 7955.ENSDARP00000052378; -.
DR PaxDb; Q2TJA6; -.
DR PRIDE; Q2TJA6; -.
DR Ensembl; ENSDART00000173523; ENSDARP00000142757; ENSDARG00000020053.
DR GeneID; 751108; -.
DR KEGG; dre:751108; -.
DR CTD; 85407; -.
DR ZFIN; ZDB-GENE-061108-3; nkd1.
DR eggNOG; ENOG502QT1X; Eukaryota.
DR GeneTree; ENSGT00440000033589; -.
DR HOGENOM; CLU_035610_1_0_1; -.
DR InParanoid; Q2TJA6; -.
DR OMA; SWERKQR; -.
DR OrthoDB; 540161at2759; -.
DR PhylomeDB; Q2TJA6; -.
DR TreeFam; TF328786; -.
DR PRO; PR:Q2TJA6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000020053; Expressed in intestine and 45 other tissues.
DR ExpressionAtlas; Q2TJA6; baseline.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0060971; P:embryonic heart tube left/right pattern formation; IMP:ZFIN.
DR GO; GO:0001754; P:eye photoreceptor cell differentiation; IEA:Ensembl.
DR GO; GO:0003146; P:heart jogging; IMP:ZFIN.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR GO; GO:0060972; P:left/right pattern formation; IMP:ZFIN.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:ZFIN.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IDA:ZFIN.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0001839; P:neural plate morphogenesis; IGI:ZFIN.
DR GO; GO:0090249; P:regulation of cell migration involved in somitogenic axis elongation; IEA:Ensembl.
DR GO; GO:0007525; P:somatic muscle development; IEA:Ensembl.
DR GO; GO:0060061; P:Spemann organizer formation; IMP:ZFIN.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:ZFIN.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040140; Nkd-like.
DR PANTHER; PTHR22611; PTHR22611; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Calcium; Cell membrane; Cytoplasm; Lipoprotein; Membrane; Metal-binding;
KW Myristate; Reference proteome; Wnt signaling pathway.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..440
FT /note="Protein naked cuticle homolog 1"
FT /id="PRO_0000301992"
FT DOMAIN 129..164
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 192..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 142
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 144
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 146
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 148
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 153
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 440 AA; 49971 MW; 4119113E20CB4C91 CRC64;
MGKLHSKHAA ICKARESPEG DSFVVNACLA RKGLDDWMVK QKYYCSSSRV DQRDCQQKNN
CELSPRDPLD EGYAEGISDE HYRLEVALPP EKTDSCSVEE RMQGTEGSAT VGPHKQLQFE
ELECAVSVEE DNRQEWTFTL YDFDNNGKVT REDITSLLHT IYEVVDASVN HSPSSSKTLR
VKLSVAPDSS QRWKNCTQTN TDTPNPKHKG EKCIEDSKTS EKKSRAFLRR YHAEHHSQQG
CQRHCVDENL ERRNHYLDLA GIENYTSRFG TAAPATEPAK PTHATRSSNQ SRSRSQEPEN
GQVHPAHHRR SQTMSTDPPA ILTRHTHALR SPKTHRTPPT QASAGRVMRR GAPPPPSVPN
QTPPHQSSGP YRRHKQRPKE ALHYRALGPS VTSGPVLEKE HVRDLPSLVL YEGGLAQVVQ
RHEHHHHHEH HHHYHHFYQS
