NKD_DROPS
ID NKD_DROPS Reviewed; 1009 AA.
AC Q29DJ1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Protein naked cuticle;
GN Name=nkd {ECO:0000250|UniProtKB:Q9VVV9}; ORFNames=GA11099;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling
CC pathway. May activate a second Wnt signaling pathway that controls
CC planar cell polarity. Required for neuroblast specification (By
CC similarity). {ECO:0000250|UniProtKB:Q9VVV9}.
CC -!- SUBUNIT: Interacts with dsh. {ECO:0000250|UniProtKB:Q9VVV9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9VVV9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q9VVV9}. Nucleus
CC {ECO:0000250|UniProtKB:Q9VVV9}.
CC -!- SIMILARITY: Belongs to the NKD family. {ECO:0000255}.
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DR EMBL; CH379070; EAL30423.2; -; Genomic_DNA.
DR AlphaFoldDB; Q29DJ1; -.
DR STRING; 7237.FBpp0286126; -.
DR PRIDE; Q29DJ1; -.
DR eggNOG; ENOG502QT1X; Eukaryota.
DR HOGENOM; CLU_314556_0_0_1; -.
DR InParanoid; Q29DJ1; -.
DR OMA; EQHTPDN; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:UniProt.
DR GO; GO:0014018; P:neuroblast fate specification; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR040140; Nkd-like.
DR PANTHER; PTHR22611; PTHR22611; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytoplasm; Developmental protein; Membrane; Metal-binding;
KW Nucleus; Reference proteome; Wnt signaling pathway.
FT CHAIN 1..1009
FT /note="Protein naked cuticle"
FT /id="PRO_0000312826"
FT DOMAIN 217..253
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 68..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..282
FT /note="Interaction with dsh"
FT /evidence="ECO:0000250"
FT REGION 328..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..613
FT /note="Required for nuclear localization and inhibition of
FT Wnt signaling"
FT /evidence="ECO:0000250"
FT REGION 619..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..416
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 111842 MW; 4AE6716ED6505DF0 CRC64;
MAGNIVKWWK HKILGGYKQF SVQECTTDSE ELMYHQVRAS SSCSAPPDLL LVSERDNNIQ
LRSPVVNIIT TPPGNASGSA SNKQQQLQQQ QGHQHHHQAM PMPHTHASRH HHHQQQQQQQ
LPQDMSSSGS HTKHLRISSS SGGKHGKYAN MQQQQQQQQT AAAATGVDED VVDAAAAAAA
APHGAHQQMH SRHLHHHKEE RIRLEEFTCD VSVEGGKSSQ PLQFSFTFYD LDGHHGKITK
DDIVGIVYTI YESIGKSVVV PHCGSKTINV RLTVSPEGKS KSAQQPAMAM GVVPASVPLP
AAALGNNNNS NNNNNNKLKK LPTGLAAMSK QMNGGNGGGG ALTTSAGTRR QHRYRPRKLI
KSDDEDDDSN SEKEKERERE RERESHAADQ QPSGSGSKGA GSKSHHHHHH HGRYQKNQSG
AKLEHQQQQQ QQLCCADTPD NTYENMLNLK QDTQAAGNEA TVPDCPSSHR QLHHQRQQDI
YMKQATQRVK MLRRARKQKY QDHCLETRQR SLSVGNDSGN WQNRHLQQSL QQQPQAAHKS
ASVSPPPLAG ELMLDGVQLR QPRPPHQSHH QQLQQQQQQR KSAECWKSAL NRNDLISIIR
ESMEKNRLCF QLNGKPQANV SPIRQPAAQQ QQQQQRQRSS TGSKIPTLIA NHSPAAPQSP
LSCSPPPCTL SLSLSSSNHP AAATCSIPVP AQAQAQGQAQ AQAQVPAPPA VIEVGGGHHQ
HDHPQPHIPI YHQQLAINPA VLAAQHSHNS AHNKLNLCGY DSFLHATICG GGSAAHSPPP
TPSNVATVQP IPKKSHNQKS LLQGYQRLEQ QQQQRSSKDY KNYGNLIYAK LSEQLQQKER
EQRRHRHKQQ QQQHHHQQQQ QQQQQQNQQQ QQQQQPLKPK EESLAEQRPP TSSSSSAGSK
IFGDALECAH LLASEEEDLP ASPPLTHSTP SKVVSTDTLI DLNDDVGEAV AEAVTESGGK
QQQQQALEAD EGQEQEVELD TSASSSMIHR YVHEHIHHHY HHFKEQQDV
