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NKG2C_MACMU
ID   NKG2C_MACMU             Reviewed;         231 AA.
AC   Q9MZK6; Q9MZK4;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=NKG2-C type II integral membrane protein;
DE   AltName: Full=CD159 antigen-like family member C;
DE   AltName: Full=NK cell receptor C;
DE   AltName: Full=NKG2-C-activating NK receptor;
DE   AltName: CD_antigen=CD159c;
GN   Name=KLRC2; Synonyms=NKG2C;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10866118; DOI=10.1007/s002510050650;
RA   LaBonte M.L., Levy D.B., Letvin N.L.;
RT   "Characterization of rhesus monkey CD94/NKG2 family members and
RT   identification of novel transmembrane-deleted forms of NKG2-A, B, C, and
RT   D.";
RL   Immunogenetics 51:496-499(2000).
CC   -!- FUNCTION: Immune activating receptor involved in self-nonself
CC       discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets,
CC       recognizes non-classical major histocompatibility MHC-E loaded with
CC       signal sequence-derived peptides from non-classical MHC-G molecules,
CC       likely playing a role in the generation and effector functions of
CC       adaptive natural killer (NK) cells and in maternal-fetal tolerance
CC       during pregnancy. Regulates the effector functions of terminally
CC       differentiated cytotoxic lymphocyte subsets, and in particular may play
CC       a role in adaptive NK cell response to viral infection. Upon MHC-E-
CC       peptide binding, transmits intracellular signals via the adapter
CC       protein TYROBP/DAP12, triggering the phosphorylation of proximal
CC       signaling molecules and cell activation.
CC       {ECO:0000250|UniProtKB:P26717}.
CC   -!- SUBUNIT: Heterodimer with KLRD1; disulfide-linked. KLRD1-KLRC2 receptor
CC       complex interacts with TYROBP/DAP12 homodimer; this interaction is
CC       necessary for the expression on the cell surface.
CC       {ECO:0000250|UniProtKB:P26717}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26717};
CC       Single-pass type II membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Natural killer cells.
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DR   EMBL; AF190934; AAF74530.1; -; mRNA.
DR   EMBL; AF190936; AAF74532.1; -; mRNA.
DR   AlphaFoldDB; Q9MZK6; -.
DR   SMR; Q9MZK6; -.
DR   STRING; 9544.ENSMMUP00000024085; -.
DR   eggNOG; ENOG502S6IE; Eukaryota.
DR   InParanoid; Q9MZK6; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0062081; F:activating MHC class Ib receptor activity; ISS:UniProtKB.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0043323; P:positive regulation of natural killer cell degranulation; ISS:UniProtKB.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; ISS:UniProtKB.
DR   GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; ISS:UniProtKB.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW   Innate immunity; Lectin; Membrane; Receptor; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..231
FT                   /note="NKG2-C type II integral membrane protein"
FT                   /id="PRO_0000046663"
FT   TOPO_DOM        1..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..93
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          116..229
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        117..128
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        145..227
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        206..219
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   VARIANT         26
FT                   /note="D -> G"
FT   VARIANT         35
FT                   /note="K -> E"
SQ   SEQUENCE   231 AA;  26389 MW;  89A9336621F37681 CRC64;
     MNKQRGTFSE VSLAQDPKRQ QRKPKDNKSS ISGTKQEIFQ VELNLQNPSL NHQGIDQIYD
     CQGLLPPPEK LTAEVLGIIC IVLMATVLKT VVLIPFLEQN NSFPNTRTQK VRHCGHCPEE
     WITYSNSCYY IGKEKRTWAE SLLACTSKNS SLLSIDNEEE MKFLTAISPS TWTGVFRDSS
     HHPWVTINGL TFKHEIKDSD HAEYNCAMLH LDRLKSVQCG SSKRYYCKHK L
 
 
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