ID   NKG2F_PANTR             Reviewed;         158 AA.
AC   Q95MI1; Q95MH7; Q95MH8; Q95MH9; Q95MI0;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=NKG2-F type II integral membrane protein;
DE   AltName: Full=NK cell receptor F;
DE   AltName: Full=NKG2-F-activating NK receptor;
GN   Name=KLRC4; Synonyms=NKG2F;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS.
RX   PubMed=11751968; DOI=10.4049/jimmunol.168.1.240;
RA   Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S.,
RA   Guethlein L.A., Uhrberg M., Parham P.;
RT   "Conservation and variation in human and common chimpanzee CD94 and NKG2
RT   genes.";
RL   J. Immunol. 168:240-252(2002).
CC   -!- FUNCTION: May play a role as a receptor for the recognition of MHC
CC       class I HLA-E molecules by NK cells.
CC   -!- SUBUNIT: Can form disulfide-bonded heterodimer with CD94.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC   -!- TISSUE SPECIFICITY: Natural killer cells.
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DR   EMBL; AF350011; AAK83798.1; -; mRNA.
DR   EMBL; AF350012; AAK83799.1; -; mRNA.
DR   EMBL; AF350013; AAK83800.1; -; mRNA.
DR   EMBL; AF350014; AAK83801.1; -; mRNA.
DR   EMBL; AF350015; AAK83802.1; -; mRNA.
DR   RefSeq; NP_001009053.1; NM_001009053.1.
DR   RefSeq; XP_016778007.1; XM_016922518.1.
DR   AlphaFoldDB; Q95MI1; -.
DR   SMR; Q95MI1; -.
DR   STRING; 9598.ENSPTRP00000054758; -.
DR   PaxDb; Q95MI1; -.
DR   GeneID; 450145; -.
DR   KEGG; ptr:450145; -.
DR   CTD; 8302; -.
DR   eggNOG; ENOG502S6IE; Eukaryota.
DR   InParanoid; Q95MI1; -.
DR   OrthoDB; 1161111at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR   GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Receptor; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..158
FT                   /note="NKG2-F type II integral membrane protein"
FT                   /id="PRO_0000046674"
FT   TOPO_DOM        1..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..158
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         7
FT                   /note="T -> I (in allele NKG2-F*02)"
FT                   /id="VAR_018703"
FT   VARIANT         22
FT                   /note="R -> K (in allele NKG2-F*02)"
FT                   /id="VAR_018704"
FT   VARIANT         35
FT                   /note="K -> E (in allele NKG2-F*02, allele NKG2-F*04 and
FT                   allele NKG2-F*05)"
FT                   /id="VAR_018705"
FT   VARIANT         70
FT                   /note="R -> K (in allele NKG2-F*02, allele NKG2-F*04 and
FT                   allele NKG2-F*05)"
FT                   /id="VAR_018706"
FT   VARIANT         90
FT                   /note="T -> I (in allele NKG2-F*04)"
FT                   /id="VAR_018707"
FT   VARIANT         119
FT                   /note="H -> R (in allele NKG2-F*02)"
FT                   /id="VAR_018708"
FT   VARIANT         126
FT                   /note="T -> I (in allele NKG2-F*04 and allele NKG2-F*05)"
FT                   /id="VAR_018709"
FT   VARIANT         144
FT                   /note="G -> R (in allele NKG2-F*02, allele NKG2-F*04 and
FT                   allele NKG2-F*05)"
FT                   /id="VAR_018710"
FT   VARIANT         151
FT                   /note="Q -> R (in allele NKG2-F*02, allele NKG2-F*03,
FT                   allele NKG2-F*04 and allele NKG2-F*05)"
FT                   /id="VAR_018711"
SQ   SEQUENCE   158 AA;  18034 MW;  2F2BC5BAFDD670DA CRC64;
     MNKQRGTYSE VSLAQDPKRQ QRKLKGNKSS ISGTKQEIFQ VELNLQNASS DHQGNDKTYH
     CKGLLPPPER LTAEVLGIIC IVLMATVLKT IVLIPCIGVL EQNNFSLNRR MQKACDCGHC
     PEEWITYSNS CYYIGKERRT WEEGVCWPVL QRTLICFL