ID   NKG7_BOVIN              Reviewed;         165 AA.
AC   Q2KJ11;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein NKG7;
DE   AltName: Full=Natural killer cell protein 7;
GN   Name=NKG7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates cytotoxic granule exocytosis in effector
CC       lymphocytes, thus acting as a critical mediator of inflammation in a
CC       broad range of infectious and non-infectious diseases (By similarity).
CC       Essential for cytotoxic degranulation of natural killer (NK) cells and
CC       CD8(+) T-cells and for the activation of CD4(+) T-cells following
CC       infection (By similarity). Plays a critical role in CD8(+) T-cell and
CC       NK cell-mediated cytolysis of target cells and contributes to the
CC       cytolytic activity via the perforin/granzyme pathway by enhancing
CC       exocytosis of LAMP1-carrying lytic granules (By similarity).
CC       Contributes to NK cell-mediated control of cancer metastasis (By
CC       similarity). {ECO:0000250|UniProtKB:Q99PA5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q16617};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16617}. Cytolytic
CC       granule membrane {ECO:0000250|UniProtKB:Q16617}; Multi-pass membrane
CC       protein {ECO:0000250|UniProtKB:Q16617}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR   EMBL; BC105575; AAI05576.1; -; mRNA.
DR   RefSeq; XP_005219600.1; XM_005219543.2.
DR   RefSeq; XP_005219601.1; XM_005219544.2.
DR   AlphaFoldDB; Q2KJ11; -.
DR   SMR; Q2KJ11; -.
DR   STRING; 9913.ENSBTAP00000012042; -.
DR   PaxDb; Q2KJ11; -.
DR   GeneID; 513006; -.
DR   CTD; 4818; -.
DR   eggNOG; ENOG502SUH4; Eukaryota.
DR   HOGENOM; CLU_133330_0_0_1; -.
DR   InParanoid; Q2KJ11; -.
DR   OrthoDB; 1488313at2759; -.
DR   TreeFam; TF330587; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0044194; C:cytolytic granule; ISS:UniProtKB.
DR   GO; GO:0101004; C:cytolytic granule membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; ISS:UniProtKB.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042832; P:defense response to protozoan; ISS:UniProtKB.
DR   GO; GO:0140507; P:granzyme-mediated programmed cell death signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0043320; P:natural killer cell degranulation; ISS:UniProtKB.
DR   GO; GO:0042267; P:natural killer cell mediated cytotoxicity; ISS:UniProtKB.
DR   GO; GO:0002420; P:natural killer cell mediated cytotoxicity directed against tumor cell target; ISS:UniProtKB.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   Pfam; PF00822; PMP22_Claudin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytolysis; Inflammatory response; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..165
FT                   /note="Protein NKG7"
FT                   /id="PRO_0000244415"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   165 AA;  17758 MW;  489D537963ECB1B3 CRC64;
     MEPCRSLALL TSSLGLVSLL VAVSTNFWFA ARGPGFSSHS GLWPSKDQVS VAGYIHVTQS
     FCILAVLWGL ISTAFLVMSC IPSLSAPGRG PIVSTFMGFA GALSLIVAMT VYTIERWNQP
     ANPQVQSFFS WSFYLGWVST LLFLCTGGLS LGAHCTTHRP DYEAV