ID   NKL_HORSE               Reviewed;         145 AA.
AC   Q8HZQ3;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 3.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Antimicrobial peptide NK-lysin;
DE   Flags: Precursor;
GN   Name=NKL;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Davis E.G., Zhang G., Sang Y., Rush B.R., Ross C., Blecha F.;
RT   "cDNA sequence of equine NK-lysin.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be an effector molecule of cytotoxic activity. Has
CC       antimicrobial activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN10122.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF538056; AAN10122.2; ALT_INIT; mRNA.
DR   RefSeq; NP_001075398.2; NM_001081929.3.
DR   AlphaFoldDB; Q8HZQ3; -.
DR   SMR; Q8HZQ3; -.
DR   STRING; 9796.ENSECAP00000031488; -.
DR   PaxDb; Q8HZQ3; -.
DR   GeneID; 100034133; -.
DR   KEGG; ecb:100034133; -.
DR   CTD; 10578; -.
DR   HOGENOM; CLU_141709_0_0_1; -.
DR   InParanoid; Q8HZQ3; -.
DR   OrthoDB; 1548681at2759; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; IBA:GO_Central.
DR   InterPro; IPR038847; Granulysin-like.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB_dom.
DR   PANTHER; PTHR15541; PTHR15541; 1.
DR   Pfam; PF03489; SapB_2; 1.
DR   SMART; SM00741; SapB; 1.
DR   SUPFAM; SSF47862; SSF47862; 1.
DR   PROSITE; PS50015; SAP_B; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..62
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000031660"
FT   PEPTIDE         63..140
FT                   /note="Antimicrobial peptide NK-lysin"
FT                   /id="PRO_0000031661"
FT   PROPEP          141..145
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000031662"
FT   DOMAIN          62..142
FT                   /note="Saposin B-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        66..138
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        69..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT   DISULFID        97..107
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
SQ   SEQUENCE   145 AA;  15880 MW;  E68C547839C24E21 CRC64;
     MTSRALLLLA SALLGTPGLT FSGLNPESYD LATAHLSDGE QFCQGLTQED LQGDLLTERE
     RQGIACWSCR KILQKLEDLV GEQPNEATIN EAASRVCRNL GLLRGACKKI MRTCLRLISR
     DILAGKKPQE VCVDIKLCKH KAGLI