ID   NKP1_KLULA              Reviewed;         210 AA.
AC   Q6CPR4;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Inner kinetochore subunit NKP1;
DE   AltName: Full=Constitutive centromere-associated network protein NKP1;
GN   Name=NKP1; OrderedLocusNames=KLLA0E02883g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   SUBUNIT, INTERACTION WITH AME1 AND OKP1, AND FUNCTION.
RX   PubMed=29046335; DOI=10.15252/embj.201796636;
RA   Schmitzberger F., Richter M.M., Gordiyenko Y., Robinson C.V., Dadlez M.,
RA   Westermann S.;
RT   "Molecular basis for inner kinetochore configuration through RWD domain-
RT   peptide interactions.";
RL   EMBO J. 36:3458-3482(2017).
CC   -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC       assembles on centromeric DNA and attaches chromosomes to spindle
CC       microtubules, mediating chromosome segregation and sister chromatid
CC       segregation during meiosis and mitosis (By similarity). Component of
CC       the inner kinetochore constitutive centromere-associated network
CC       (CCAN), which serves as a structural platform for outer kinetochore
CC       assembly (PubMed:29046335). {ECO:0000250|UniProtKB:Q12493,
CC       ECO:0000269|PubMed:29046335}.
CC   -!- SUBUNIT: Component of the inner kinetochore constitutive centromere-
CC       associated network (CCAN) (also known as central kinetochore CTF19
CC       complex in yeast) (By similarity). NKP1 interacts directly with OKP1
CC       and AME1 (PubMed:29046335). {ECO:0000250|UniProtKB:Q12493,
CC       ECO:0000269|PubMed:29046335}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q12493}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q12493}.
CC   -!- SIMILARITY: Belongs to the NKP1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99162.1; -; Genomic_DNA.
DR   RefSeq; XP_454075.1; XM_454075.1.
DR   AlphaFoldDB; Q6CPR4; -.
DR   SMR; Q6CPR4; -.
DR   EnsemblFungi; CAG99162; CAG99162; KLLA0_E02883g.
DR   GeneID; 2894038; -.
DR   KEGG; kla:KLLA0_E02883g; -.
DR   HOGENOM; CLU_1310316_0_0_1; -.
DR   InParanoid; Q6CPR4; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Kinetochore; Meiosis;
KW   Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Inner kinetochore subunit NKP1"
FT                   /id="PRO_0000443074"
SQ   SEQUENCE   210 AA;  24891 MW;  AA056C7EB2230E1D CRC64;
     MDLESEIIQL VRQNIRPKFP SLNDEQQARL DNALKYDVNY DILKKELVEY IDDWKRNEYY
     DVLTNIGDLQ RLDLGNMLNG DGVSFPKLHS DLANLPRFRL IDNENEMDQS LLHKYDSLRT
     RLIEKCRAIE LIRSATNTDV NYQDINSMLS VVELRQWRDE IQMEWKELAQ NLELILKTWP
     DLTEEKRSKL LQLIDSSSLK SILHIKDNIE