NKP1_SCHPO
ID NKP1_SCHPO Reviewed; 233 AA.
AC O94716;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Inner kinetochore subunit fta4;
DE AltName: Full=Constitutive centromere-associated network protein fta4;
DE AltName: Full=Sim4 complex subunit fta4;
DE AltName: Full=Sim4-mal2-associated protein 4;
GN Name=fta4; Synonyms=sma4; ORFNames=SPCC1393.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT "Molecular analysis of kinetochore architecture in fission yeast.";
RL EMBO J. 24:2919-2930(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-189 AND THR-191, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC assembles on centromeric DNA and attaches chromosomes to spindle
CC microtubules, mediating chromosome segregation and sister chromatid
CC segregation during meiosis and mitosis. Component of the inner
CC kinetochore constitutive centromere-associated network (CCAN), which
CC serves as a structural platform for outer kinetochore assembly
CC (PubMed:16079914). Fta2, fta3 and fta4 associate with the central core
CC (cnt) and inner repeat (inr) region of the centromere
CC (PubMed:16079914). {ECO:0000269|PubMed:16079914}.
CC -!- SUBUNIT: Component of the inner kinetochore constitutive centromere-
CC associated network (CCAN) (also known as central kinetochore Sim4
CC complex in fission yeast), which is composed of at least cnl2, cnp3,
CC cnp20, fta1, fta2, fta3, fta4, fta6, fta7, mal2, mhf1, mhf2, mis6,
CC mis15, mis17, sim4 and wip1. {ECO:0000269|PubMed:16079914}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC -!- SIMILARITY: Belongs to the NKP1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB38160.1; -; Genomic_DNA.
DR PIR; T40952; T40952.
DR RefSeq; NP_587962.1; NM_001022953.2.
DR AlphaFoldDB; O94716; -.
DR SMR; O94716; -.
DR BioGRID; 275303; 8.
DR STRING; 4896.SPCC1393.04.1; -.
DR iPTMnet; O94716; -.
DR PaxDb; O94716; -.
DR EnsemblFungi; SPCC1393.04.1; SPCC1393.04.1:pep; SPCC1393.04.
DR GeneID; 2538719; -.
DR KEGG; spo:SPCC1393.04; -.
DR PomBase; SPCC1393.04; fta4.
DR VEuPathDB; FungiDB:SPCC1393.04; -.
DR eggNOG; ENOG502S9QD; Eukaryota.
DR HOGENOM; CLU_1190479_0_0_1; -.
DR InParanoid; O94716; -.
DR OMA; HNRIVYS; -.
DR PhylomeDB; O94716; -.
DR PRO; PR:O94716; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IC:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IC:PomBase.
DR InterPro; IPR025207; Sim4_Fta4.
DR PANTHER; PTHR42040; PTHR42040; 1.
DR Pfam; PF13093; FTA4; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Kinetochore; Microtubule; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..233
FT /note="Inner kinetochore subunit fta4"
FT /id="PRO_0000290640"
FT MOD_RES 189
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 191
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 233 AA; 27149 MW; E2983A3D7EB79EB9 CRC64;
MDIYEHKKSF MERQIRLLNR PMRPPKDWKL PLKSGQLSES VVETVFQRLQ LRIQKHAKLN
YSHQATQHVA AQIRKLYEQN SAIEDITFLN PLFYGEIDLS NLDSVKSLPH PWPFQKESRP
VEKDEEQEKF NRLTGELLGL LTTLSELEQE RSELEQIEKM LEPFEDGPSS IHTNMWKKNP
ELISTLNSTN TMVAKINSLL RGVSFPSLNN DNQEASLEDE IRSQLFEKTI SDD
