ID   NKP2_KLULA              Reviewed;         151 AA.
AC   Q6CSR8;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Inner kinetochore subunit NKP2;
DE   AltName: Full=Constitutive centromere-associated network protein NKP2;
GN   Name=NKP2; OrderedLocusNames=KLLA0C18425g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   SUBUNIT, INTERACTION WITH AME1 AND OKP1, AND FUNCTION.
RX   PubMed=29046335; DOI=10.15252/embj.201796636;
RA   Schmitzberger F., Richter M.M., Gordiyenko Y., Robinson C.V., Dadlez M.,
RA   Westermann S.;
RT   "Molecular basis for inner kinetochore configuration through RWD domain-
RT   peptide interactions.";
RL   EMBO J. 36:3458-3482(2017).
CC   -!- FUNCTION: Component of the kinetochore, a multiprotein complex that
CC       assembles on centromeric DNA and attaches chromosomes to spindle
CC       microtubules, mediating chromosome segregation and sister chromatid
CC       segregation during meiosis and mitosis (By similarity). Component of
CC       the inner kinetochore constitutive centromere-associated network
CC       (CCAN), which serves as a structural platform for outer kinetochore
CC       assembly (PubMed:29046335). {ECO:0000250|UniProtKB:Q06162,
CC       ECO:0000269|PubMed:29046335}.
CC   -!- SUBUNIT: Component of the inner kinetochore constitutive centromere-
CC       associated network (CCAN) (also known as central kinetochore CTF19
CC       complex in yeast) (By similarity). NKP2 interacts directly with OKP1
CC       and AME1 (PubMed:29046335). {ECO:0000250|UniProtKB:Q06162,
CC       ECO:0000269|PubMed:29046335}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q06162}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q06162}.
CC   -!- SIMILARITY: Belongs to the NKP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382123; CAH01872.1; -; Genomic_DNA.
DR   RefSeq; XP_453021.1; XM_453021.1.
DR   AlphaFoldDB; Q6CSR8; -.
DR   SMR; Q6CSR8; -.
DR   EnsemblFungi; CAH01872; CAH01872; KLLA0_C18425g.
DR   GeneID; 2892138; -.
DR   KEGG; kla:KLLA0_C18425g; -.
DR   HOGENOM; CLU_1731740_0_0_1; -.
DR   InParanoid; Q6CSR8; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..151
FT                   /note="Inner kinetochore subunit NKP2"
FT                   /id="PRO_0000443075"
FT   COILED          44..64
FT                   /evidence="ECO:0000255"
FT   COILED          102..122
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   151 AA;  17658 MW;  7A703D0AA74146E5 CRC64;
     MLHEVLYKHL DGILVSRLYT EDQFVDLFSR TIPESNTVIA SQLYKSYEEN DQRIIEKIDK
     LIDNKLSLIR VELEREQIED SISLEEVNKL LHSIDDMLQQ HLNQLNIELD NKNTKLLKYA
     MELSDIEAID TSMYDNVAKL ITDMETNQPS S