NKPD1_HUMAN
ID NKPD1_HUMAN Reviewed; 610 AA.
AC Q17RQ9; B7ZLG6; D6RH15; Q8N2A2;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=NTPase KAP family P-loop domain-containing protein 1;
GN Name=NKPD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03547.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
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DR EMBL; AK090919; BAC03547.1; ALT_SEQ; mRNA.
DR EMBL; AC005757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117228; AAI17229.1; -; mRNA.
DR EMBL; BC143792; AAI43793.1; -; mRNA.
DR AlphaFoldDB; Q17RQ9; -.
DR STRING; 9606.ENSP00000321976; -.
DR iPTMnet; Q17RQ9; -.
DR PhosphoSitePlus; Q17RQ9; -.
DR BioMuta; NKPD1; -.
DR DMDM; 121945557; -.
DR MassIVE; Q17RQ9; -.
DR PaxDb; Q17RQ9; -.
DR PeptideAtlas; Q17RQ9; -.
DR PRIDE; Q17RQ9; -.
DR ProteomicsDB; 61162; -.
DR Antibodypedia; 49151; 73 antibodies from 13 providers.
DR Ensembl; ENST00000589776.1; ENSP00000468649.1; ENSG00000179846.11.
DR UCSC; uc021uvt.1; human.
DR GeneCards; NKPD1; -.
DR HGNC; HGNC:24739; NKPD1.
DR HPA; ENSG00000179846; Tissue enriched (skin).
DR neXtProt; NX_Q17RQ9; -.
DR OpenTargets; ENSG00000179846; -.
DR PharmGKB; PA134993651; -.
DR VEuPathDB; HostDB:ENSG00000179846; -.
DR eggNOG; KOG0502; Eukaryota.
DR GeneTree; ENSGT00650000093443; -.
DR HOGENOM; CLU_025247_1_0_1; -.
DR InParanoid; Q17RQ9; -.
DR OMA; QCLLRCT; -.
DR PhylomeDB; Q17RQ9; -.
DR PathwayCommons; Q17RQ9; -.
DR Pharos; Q17RQ9; Tdark.
DR PRO; PR:Q17RQ9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q17RQ9; protein.
DR Bgee; ENSG00000179846; Expressed in skin of abdomen and 65 other tissues.
DR Genevisible; Q17RQ9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR011646; KAP_P-loop.
DR Pfam; PF07693; KAP_NTPase; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..610
FT /note="NTPase KAP family P-loop domain-containing protein
FT 1"
FT /id="PRO_0000294150"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..414
FT /note="KAP NTPase"
FT REGION 540..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 118
FT /note="V -> L (in dbSNP:rs3810144)"
FT /id="VAR_033146"
FT CONFLICT 336
FT /note="R -> H (in Ref. 1; BAC03547)"
FT /evidence="ECO:0000305"
FT CONFLICT 461
FT /note="A -> E (in Ref. 1; BAC03547)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 67780 MW; 88A9BE1197BF20CA CRC64;
MQQEAAQRES EELQHVQWRP RAVSGWGVPQ LLWYLVFLQP IITEVHLRRR NVQFLFIRFS
AWQYAGTDKL WAGLVTTLCE GIRRHYGALP FSVYSVLGNK PATRQDCCQS EWHCRRRVCL
GLLALLAALG LGVGLLYLSL GGHALGHGSP SGSLLKVFGG AATTLSGSGL LMAVYSVGKH
LFVSQRKKIE RLVSREKFGS QLGFMCEVKK EVELLTDFLC FLEIYQRRRL RVVLEVTGLD
TCYPERVVGV LNAINTLLSD SHAPFIFILV VDPSILAACL ESAGNMKGTA DNGYLFLNRT
VTLPFSVPIM GRRTKLQFLH DAVQSRDDLL YREMTRKPWL PGDAGGESAQ LLAVQAQAGT
ERGQGRIDDE AARRIQEALF CLHDERDCLY EYVPDNVVSM RRIVNTVPIT VRLLQQQQQQ
GDFGGPTPRQ AVAWVVLANQ WPCRLSWALQ CLEDRQQTGG APEGRARLWD VFRDNSRELH
TMTKALQNVL DLDGDPELFE RFLGADFPFT VAEAQSLLRC TVNLDHSIRR RMGLIRAVSA
LKPPSPPKSP TRDTPHAAHR ANSASRAPPS GRASGQAGEG HHTGDLAHRG KLWPVACALF
RPGQSSPGGP
